The Marginal Costs of Adverse Drug Events Associated With Exposures to Anticoagulants and Hypoglycemic Agents During Hospitalization

BACKGROUND: Anticoagulants and hypoglycemic agents are 2 of the most challenging drug classes for medical management in the hospital resulting in many adverse drug events (ADEs). OBJECTIVE: Estimating the marginal cost (MC) of ADEs associated with anticoagulants and hypoglycemic agents for adults in 5 patient groups during their hospital stay and the total annual ADE costs for all patients exposed to these drugs during their stay. RESEARCH DESIGN AND SUBJECT: Data are from 2010 to 2013 Healthcare Cost and Utilization Project (HCUP) State Inpatient Databases and Medicare Patient Safety Monitoring System (MPSMS). Deidentified patients were linked using probabilistic matching in the same hospital and year for 5 patient groups. ADE information was obtained from the MPSMS using retrospective structured record review. Costs were derived using HCUP cost-to-charge ratios. MC estimates were made using Extended Estimating Equations controlling for patient characteristics, comorbidities, hospital procedures, and hospital characteristics. MC estimates were applied to the 2013 HCUP National Inpatient Sample to estimate annual ADE costs. RESULTS: Adjusted MC estimates were smaller than unadjusted measures with most groups showing estimates that were at least 50% less. Adjusted anticoagulant ADE costs added >45% and Hypoglycemic ADE costs added >20% to inpatient costs. The 2013 hospital cost estimates for ADEs associated with anticoagulants and hypoglycemic agents were >$2.5 billion for each drug class. CONCLUSIONS: This study demonstrates the importance of accounting for confounders in the estimation of ADEs, and the importance of separate estimates of ADE costs by drug class

Adverse effect · Confounding · Drug · Drug class · Health care · Healthcare Cost and Utilization Project · Inpatient care · Intensive care medicine · Medical emergency · Atrial Fibrillation Management and Outcomes · Emergency Medicine · Internal Medicine · Medicine · Patient Safety and Medication Errors · Pharmacology · Pharmacovigilance and Adverse Drug Reactions

• Direct Medical Costs of Parkinson’s Disease in Southern China

  Open Access•Hui Zhang, Wenjing Zhou et al.•International Journal of…•2022

  Incluir item

• The Nature of Adverse Events in Hospitalized Patients

  LUCIAN L LEAPE, Troyen A Brennan et al.•New England Journal of Medicine•1991

  Incluir item

• Incidence of Adverse Events and Negligence in Hospitalized Patients

  Troyen A Brennan, LUCIAN L LEAPE et al.•New England Journal of Medicine•1991

  Incluir item

• Costs of Intravenous Adverse Drug Events in Academic and Nonacademic Intensive Care Units

  Teryl K Nuckols, Susan M Paddock et al.•Medical Care•2008

  Incluir item

• Marginal Hospital Cost of Surgery-related Hospital-acquired Pressure Ulcers

  William D Spector, Rhona Limcangco et al.•Medical Care•2016

  Incluir item

• Performance of International Classification of Diseases, 9th Revision, Clinical Modification Codes as an Adverse Drug Event Surveillance System

  Paul Hougland, Wu Xu et al.•Medical Care•2006

  Incluir item