The Effects of Chronic Prenatal Exposure to Nicotine on the Behavior of Guinea Pigs (Cavia porcellus)
Bibliographic Data
| ID | 10121421 |
|---|---|
| Authors | Josephine M Johns (University of Georgia, corresponding author), Paul A Walters, Paul Walters (University of Georgia), Laura I Zimmerman (University of Georgia) |
| Year | 1993 |
| Volume | 120 |
| Issue | 1 |
| Pages | 49-63 |
| Publication date | 1993-01-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | The Journal of General Psychology (JOURNAL) |
| Journal identifiers | ISSN: 0022-1309 • E-ISSN: 1940-0888 |
| Publisher | Taylor & Francis (PUBLISHER • GB) |
| DOI | 10.1080/00221309.1993.9917861 |
| PMID | 8340785 |
| OpenAlex | W1967713563 |
| Language | EN |
| References cited | 12 |
Three groups of 15 offspring from guinea pig dams were injected twice daily throughout gestation with one of three doses (0.5, 1.5 or 2.5 mg/kg) of nicotine-hydrogen tartrate. These offspring and 15 saline-exposed offspring were tested on several behavioral measures. Offspring of nicotine-treated dams had significantly lower rates of spontaneous alternation as neonates. The 1.5 and 2.5 mg/kg nicotine-exposed offspring also alternated less at puberty than control offspring and would not enter an unfamiliar stimulus alley that a majority of controls entered. Nicotine offspring, as adults, performed significantly poorer than their controls on errors and trials to criterion on a discrimination and reversal task. Prenatal nicotine treatment resulted in performance deficits on both learned and innate behavioral measures throughout development and adulthood
Biology · Cavia · Gestation · Guinea pig · Nicotine · Offspring · Pregnancy · Saline · Spontaneous alternation · Internal Medicine · Medicine · Neuroendocrine regulation and behavior · Physiology · Psychology
| Highly cited | No |
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