The Statin–Iron Nexus

Anti-Inflammatory Intervention for Arterial Disease Prevention

Bibliographic Data

ID11019136
AuthorsLeo R Zacharski (Leo R. Zacharski is with Research Service, Veterans Affairs Hospital, White River Junction, VT, and the Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH. At the time of the study, Ralph G. DePalma was with Veterans Affairs, Sierra Nevada Health Care Network, University of Nevada School of Medicine, Reno, and the VA Central Office, Uniformed University of the Health Sciences, Bethesda, MD. Galina Shamayeva and Bruce K. Chow are with the Veteran Affairs Cooperative Studies...), Ralph G DePalma (Leo R. Zacharski is with Research Service, Veterans Affairs Hospital, White River Junction, VT, and the Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH. At the time of the study, Ralph G. DePalma was with Veterans Affairs, Sierra Nevada Health Care Network, University of Nevada School of Medicine, Reno, and the VA Central Office, Uniformed University of the Health Sciences, Bethesda, MD. Galina Shamayeva and Bruce K. Chow are with the Veteran Affairs Cooperative Studies...), Galina Shamayeva (Leo R. Zacharski is with Research Service, Veterans Affairs Hospital, White River Junction, VT, and the Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH. At the time of the study, Ralph G. DePalma was with Veterans Affairs, Sierra Nevada Health Care Network, University of Nevada School of Medicine, Reno, and the VA Central Office, Uniformed University of the Health Sciences, Bethesda, MD. Galina Shamayeva and Bruce K. Chow are with the Veteran Affairs Cooperative Studies...), Bruce K Chow (0000-0003-2976-8710, Leo R. Zacharski is with Research Service, Veterans Affairs Hospital, White River Junction, VT, and the Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH. At the time of the study, Ralph G. DePalma was with Veterans Affairs, Sierra Nevada Health Care Network, University of Nevada School of Medicine, Reno, and the VA Central Office, Uniformed University of the Health Sciences, Bethesda, MD. Galina Shamayeva and Bruce K. Chow are with the Veteran Affairs Cooperative Studies...)
Year2013
Volume103
Issue4
Pagese105-e112
Publication date2013-04-01
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2012.301163
PMID23409890
PMCIDPMC3673278
LanguageEN
References cited133

Objectives. We postulated the existence of a statin–iron nexus by which statins improve cardiovascular disease outcomes at least partially by countering proinflammatory effects of excess iron stores. Methods. Using data from a clinical trial of iron (ferritin) reduction in advanced peripheral arterial disease, the Iron and Atherosclerosis Study, we compared effects of ferritin levels versus high-density lipoprotein to low-density lipoprotein ratios (both were randomization variables) on clinical outcomes in participants receiving and not receiving statins. Results. Statins increased high-density lipoprotein to low-density lipoprotein ratios and reduced ferritin levels by noninteracting mechanisms. Improved clinical outcomes were associated with lower ferritin levels but not with improved lipid status. Conclusions. There are commonalities between the clinical benefits of statins and the maintenance of physiologic iron levels. Iron reduction may be a safe and low-cost alternative to statins

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