Hepatitis A Virus Immunity and Seroconversion Among Contacts of Acute Hepatitis A Patients in Amsterdam, 1996–2000

An Evaluation of Current Prevention Policy

Bibliographic Data

ID11019772
AuthorsGerard J B Sonder (0000-0003-1349-4225, Gerard J. B. Sonder, Jim E. van Steenbergen, Lian P. M. J. Bovee, Roel A. Coutinho, and Anneke van den Hoek are with the GG&GD, Department of Infectious Diseases, Municipal Health Service, Amsterdam, the Netherlands. Paul G. H. Peerbooms is with GG&GD Municipal Health Laboratory, Amsterdam. Dr. Sonder also is with LCR, National Coordination Center for Travelers Health Advice, Amsterdam. Dr. van Steenbergen also is with LCI, Coordination Communicable Disease Control, Utrecht, the Netherlands. Dr. Coutinho...), Jim E van Steenbergen (Gerard J. B. Sonder, Jim E. van Steenbergen, Lian P. M. J. Bovee, Roel A. Coutinho, and Anneke van den Hoek are with the GG&GD, Department of Infectious Diseases, Municipal Health Service, Amsterdam, the Netherlands. Paul G. H. Peerbooms is with GG&GD Municipal Health Laboratory, Amsterdam. Dr. Sonder also is with LCR, National Coordination Center for Travelers Health Advice, Amsterdam. Dr. van Steenbergen also is with LCI, Coordination Communicable Disease Control, Utrecht, the Netherlands. Dr. Coutinho...), Jim van Steenbergen (0000-0002-3652-5146, GGD Amsterdam), Lian P M J Bovee (Gerard J. B. Sonder, Jim E. van Steenbergen, Lian P. M. J. Bovee, Roel A. Coutinho, and Anneke van den Hoek are with the GG&GD, Department of Infectious Diseases, Municipal Health Service, Amsterdam, the Netherlands. Paul G. H. Peerbooms is with GG&GD Municipal Health Laboratory, Amsterdam. Dr. Sonder also is with LCR, National Coordination Center for Travelers Health Advice, Amsterdam. Dr. van Steenbergen also is with LCI, Coordination Communicable Disease Control, Utrecht, the Netherlands. Dr. Coutinho...), Lian Bovée (GGD Amsterdam), Paul G H Peerbooms (Gerard J. B. Sonder, Jim E. van Steenbergen, Lian P. M. J. Bovee, Roel A. Coutinho, and Anneke van den Hoek are with the GG&GD, Department of Infectious Diseases, Municipal Health Service, Amsterdam, the Netherlands. Paul G. H. Peerbooms is with GG&GD Municipal Health Laboratory, Amsterdam. Dr. Sonder also is with LCR, National Coordination Center for Travelers Health Advice, Amsterdam. Dr. van Steenbergen also is with LCI, Coordination Communicable Disease Control, Utrecht, the Netherlands. Dr. Coutinho...), Roel A Coutinho (Gerard J. B. Sonder, Jim E. van Steenbergen, Lian P. M. J. Bovee, Roel A. Coutinho, and Anneke van den Hoek are with the GG&GD, Department of Infectious Diseases, Municipal Health Service, Amsterdam, the Netherlands. Paul G. H. Peerbooms is with GG&GD Municipal Health Laboratory, Amsterdam. Dr. Sonder also is with LCR, National Coordination Center for Travelers Health Advice, Amsterdam. Dr. van Steenbergen also is with LCI, Coordination Communicable Disease Control, Utrecht, the Netherlands. Dr. Coutinho...), Anneke van den Hoek (Gerard J. B. Sonder, Jim E. van Steenbergen, Lian P. M. J. Bovee, Roel A. Coutinho, and Anneke van den Hoek are with the GG&GD, Department of Infectious Diseases, Municipal Health Service, Amsterdam, the Netherlands. Paul G. H. Peerbooms is with GG&GD Municipal Health Laboratory, Amsterdam. Dr. Sonder also is with LCR, National Coordination Center for Travelers Health Advice, Amsterdam. Dr. van Steenbergen also is with LCI, Coordination Communicable Disease Control, Utrecht, the Netherlands. Dr. Coutinho...)
Year2004
Volume94
Issue9
Pages1620-1626
Publication date2004-09-01
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.94.9.1620
PMID15333325
OpenAlexW2147905929
LanguageEN
Citations received1
References cited12

Objectives. We evaluated the hepatitis A virus (HAV) control policy (hygienic precautions and passive immunization with immune globulin) for “household contacts” (defined as all people who lived in the same house and who shared the same toilet with the patient, people who took care of an HAV-infected child, and sexual partners of the patient) of acute hepatitis A patients between 1996 and 2000. Methods. We examined the characteristics and the serological outcomes of household contacts. All susceptible contacts were invited for retesting 6 weeks after they received immune globulin. Results. Of 1242 contacts of 569 HAV patients, more than 50% (n = 672) were found to be HAV immune. Among the remaining contacts, 161 (28.2%) had a concurrent infection, and 86 of these individuals were symptomatic. The remaining 409 susceptible contacts received immune globulin, with 186 (45%) returning for retesting 6 weeks later (64 [34%] were infected, but only 12 had symptoms). Conclusions. Immune globulin does not protect all household contacts from HAV infection; however, it attenuates symptoms and effectively reduces further HAV transmission

Antibody · Hepatitis · Hepatitis A · Hepatitis A vaccine · Hepatitis a virus · Immune system · Immunity · Seroconversion · Serology · Transmission (telecommunications) · Virus · Hepatitis Viruses Studies and Epidemiology · Immunology · Medicine · Viral gastroenteritis research and epidemiology · Viral Infections and Immunology Research · Virology · Pediatrics

Tools

Open DOI