The Prompted Optional Randomization Trial
A New Design for Comparative Effectiveness Research
Bibliographic Data
Randomized controlled trials are the gold standard for medical evidence because randomization provides the best-known protection against confounding of results. Randomization has practical and ethical problems that limit the number of trials that can be conducted, however. A different method for collecting clinical data retains the statistically useful properties of randomization without incurring its practical and ethical challenges. A computerized prompt introduces a random element into clinical decision-making that can be instantly overridden if it conflicts with optimal patient care. This creates a weak form of randomization that still eliminates the effect of all confounders, can be carried out without disturbing routine clinical care, and arguably will not require research-grade informed consent
Alternative medicine · Clinical trial · Comparative effectiveness research · Confounding · Family medicine · Gold standard (test) · Informed consent · Medical physics · Random assignment · Randomization · Randomized controlled trial · Research design · Restricted randomization · Statistics · Ethics in Clinical Research · Health Systems, Economic Evaluations, Quality of Life · Mathematics · Medicine · Statistical Methods in Clinical Trials · Surgery
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