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Early menopause, number of reproductive years, and bone mineral density in postmenopausal women

Bibliographic Data

ID11025013
AuthorsD Kritz-Silverstein, Donna Kritz‐Silverstein (0000-0003-0872-636X, University of California San Diego), E Barrett-Connor
Year1993
Volume83
Issue7
Pages983-988
Publication date1993-07-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.83.7.983
PMID8328621
OpenAlexW2034183904
LanguageEN
Citations received9
References cited16

OBJECTIVES. Previous studies have reported positive associations of age at menopause with bone density and inverse associations of age at menarche with bone density. This study examined the relationships of early age at menopause and number of reproductive years (defined as age at menopause minus age at menarche) with bone density in postmenopausal women. METHODS. The subjects were 555 women aged 60 to 89 years who had had either natural menopause (n = 391) or hysterectomy with bilateral oophorectomy (n = 164). Bone density was measured at the ultradistal wrist, midshaft radius, lumbar spine, and hip. RESULTS. Women who had had early menopause and those with the fewest reproductive years had significantly lower bone density at all sites. After adjustment for covariates, both age at menopause and number of reproductive years had significant positive associations with bone density at every site, and total number of reproductive years explained more of the variance in bone mineral density than did either age at menarche or age at menopause. CONCLUSIONS. Elderly women reporting early menopause or fewer reproductive years have more osteoporosis. The number of reproductive years may be more helpful than age at menopause in identifying women at increased risk of osteoporosis

Bone density · Bone mineral · Gynecology · Menarche · Menopause · Obstetrics · Osteoporosis · Bone health and osteoporosis research · Bone Metabolism and Diseases · Endocrinology · Medicine · Menopause: Health Impacts and Treatments

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Unique citing works9
Citations per year0.32
Citation span1998 - 2024 (27)
Citation velocityrecent
Highly citedNo
Citation typesNeutral: 9

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