Directly Observed Highly Active Antiretroviral Therapy for HIV-Infected Children in Cambodia

Bibliographic Data

ID11026645
AuthorsPatricia Myung (At the time of the study, David Pugatch, Mark Lurie, and Joseph I. Harwell were with Brown Medical School, Providence, RI. Mark F. Brady and Patricia Myung were students at Brown Medical School, Providence. Phok Many and John Tucker were with the Maryknoll Little Sprouts program, Phnom Penh, Cambodia.), David Pugatch (At the time of the study, David Pugatch, Mark Lurie, and Joseph I. Harwell were with Brown Medical School, Providence, RI. Mark F. Brady and Patricia Myung were students at Brown Medical School, Providence. Phok Many and John Tucker were with the Maryknoll Little Sprouts program, Phnom Penh, Cambodia.), Mark F Brady (0000-0001-6700-2981, At the time of the study, David Pugatch, Mark Lurie, and Joseph I. Harwell were with Brown Medical School, Providence, RI. Mark F. Brady and Patricia Myung were students at Brown Medical School, Providence. Phok Many and John Tucker were with the Maryknoll Little Sprouts program, Phnom Penh, Cambodia.), Phok Many (At the time of the study, David Pugatch, Mark Lurie, and Joseph I. Harwell were with Brown Medical School, Providence, RI. Mark F. Brady and Patricia Myung were students at Brown Medical School, Providence. Phok Many and John Tucker were with the Maryknoll Little Sprouts program, Phnom Penh, Cambodia.), Joseph I Harwell (0000-0002-8853-9603, At the time of the study, David Pugatch, Mark Lurie, and Joseph I. Harwell were with Brown Medical School, Providence, RI. Mark F. Brady and Patricia Myung were students at Brown Medical School, Providence. Phok Many and John Tucker were with the Maryknoll Little Sprouts program, Phnom Penh, Cambodia.), Mark N Lurie (0000-0002-3153-1715, Andrews University), Mark Lurie (At the time of the study, David Pugatch, Mark Lurie, and Joseph I. Harwell were with Brown Medical School, Providence, RI. Mark F. Brady and Patricia Myung were students at Brown Medical School, Providence. Phok Many and John Tucker were with the Maryknoll Little Sprouts program, Phnom Penh, Cambodia.), John Tucker (At the time of the study, David Pugatch, Mark Lurie, and Joseph I. Harwell were with Brown Medical School, Providence, RI. Mark F. Brady and Patricia Myung were students at Brown Medical School, Providence. Phok Many and John Tucker were with the Maryknoll Little Sprouts program, Phnom Penh, Cambodia.), John A Tucker (0000-0002-2964-8949, Andrews University)
Year2007
Volume97
Issue6
Pages974-977
Publication date2007-06-01
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2005.083253
PMID17463375
PMCIDPMC1874195
OpenAlexW2082335007
LanguageEN
Citations received3
References cited9

Antiretroviral medications are becoming available for HIV-infected children in resource-limited settings. Maryknoll, an international Catholic charity, provided directly observed antiretroviral therapy to HIV-infected children in Phnom Penh, Cambodia. Child care workers administered generic antiretroviral drugs twice daily to children, ensuring adherence. Treatment began with 117 late-stage HIV-infected children; 22 died of AIDS during the first 6 months. The rest were treated for at least 6 months and showed CD4 count increases comparable to those achieved in US and European children. Staffing cost for this program was approximately US $5 per child per month, or 15% more than the price of the medications. Drug toxicities were uncommon and easily managed. Directly observed antiretroviral therapy appears to be a promising, low-cost strategy for ensuring adherent treatment for HIV-infected children in a resource-limited setting

ANTIRETROVIRAL AGENTS · Antiretroviral therapy · Antiretroviral treatment · Developing country · Economic growth · Family medicine · Human immunodeficiency virus (HIV) · Sida · Staffing · Viral disease · Viral load · HIV Research and Treatment · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medicine · Nursing · Pediatrics

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