The effect of postmenopausal estrogen therapy on the risk of non-insulin-dependent diabetes mellitus

Bibliographic Data

ID11028695
AuthorsL L Gabal (University of California San Diego), D Goodman-Gruen, Deborah Goodman‐Gruen, E Barrett-Connor
Year1997
Volume87
Issue3
Pages443-445
Publication date1997-03-01
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.87.3.443
PMID9096551
OpenAlexW2142200568
LanguageEN
Citations received3
References cited17

OBJECTIVES: This study examined the effect of postmenopausal estrogen replacement therapy on the incidence of non-insulin-dependent diabetes in women. METHODS: Postmenopausal women aged 50 through 70 years (n=848) without diagnosed diabetes at baseline were followed for 10 to 15 years for incident diabestes. RESULTS: Over the average 11.5 year follow-ip, there were 105 new cases of diabetes. The age-adjusted relative-risk for development of diabetes was nonsignificantly lower for women with continuous estrogen replacement therapy use than for never users. After adjustment for major covariates, a nonsignificant linear trend with increasing duration of estrogen replacement therapy was reversed. CONCLUSIONS: This study suggests that previous results showing a reduced risk of diabetes in women using estrogen may have been due to selection bias regarding who is prescribed estrogen, confounding factors, or differential diagnostic efforts

Diabetes mellitus · Estrogen · Estrogen replacement therapy · Estrogen therapy · Insulin · Postmenopausal women · Endocrinology · Estrogen and related hormone effects · Internal Medicine · Medicine · Menopause: Health Impacts and Treatments · Phytoestrogen effects and research

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