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Evaluating Public Health Interventions

8. Causal Inference for Time-Invariant Interventions

Bibliographic Data

ID11031701
AuthorsDonna Spiegelman (0000-0003-4006-4650, Donna Spiegelman is with the departments of Epidemiology, Biostatistics, Nutrition, and Global Health, Harvard T. H. Chan School of Public Health, Boston, MA. Xin Zhou is with the departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health.), Xin Zhou (0000-0003-2640-6431, Donna Spiegelman is with the departments of Epidemiology, Biostatistics, Nutrition, and Global Health, Harvard T. H. Chan School of Public Health, Boston, MA. Xin Zhou is with the departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health.)
Year2018
Volume108
Issue9
Pages1187-1190
Publication date2018-09-01
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2018.304530
PMID30024804
OpenAlexW2883925922
LanguageEN
Citations received2
References cited16

We provide an overview of classical and newer methods for the control of confounding of time-invariant interventions to permit causal inference in public health evaluations. We estimated the causal effect of gender on all-cause mortality in a large HIV care and treatment program supported by the President’s Emergency Program for AIDS Relief in Dar es Salaam, Tanzania, between 2004 and 2012. We compared results from multivariable modeling, three propensity score methods, inverse-probability weighting, doubly robust methods, and targeted maximum likelihood estimation. Considerable confounding was evident, and, as expected by theory, all methods considered gave the same result, a statistically significant approximately 20% increased mortality rate in men. In general, there is no clear advantage of any of these methods for causal inference over classical multivariable modeling, from the point of view of either bias reduction or efficiency. Rather, given sufficient data to adequately fit the multivariable model to the data, multivariable modeling will yield causal estimates with the greatest statistical efficiency. All methods can adjust only for well-measured confounders—if there are unmeasured or poorly measured confounders, none of these methods will yield causal estimates

Causal inference · Confounding · Econometrics · Inverse probability weighting · Marginal structural model · Multivariable calculus · Point estimation · Propensity score matching · Psychiatry · Psychological intervention · Statistical inference · Statistics · Weighting · Advanced Causal Inference Techniques · Health Systems, Economic Evaluations, Quality of Life · Mathematics · Medicine · Statistical Methods and Inference

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Citations per year0.29
Citation span2019 - 2020 (2)
Highly citedNo

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