H1N1 Influenza Vaccination During Pregnancy and Fetal and Neonatal Outcomes

Bibliographic Data

ID11033358
AuthorsDeshayne B Fell (0000-0002-5548-3228, Deshayne B. Fell, Ann E. Sprague, and Mark C. Walker are with Better Outcomes Registry & Network (BORN) Ontario and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Ning Liu is with the Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Abdool S. Yasseen III and Shi-Wu Wen are with the Ottawa Hospital Research Institute. Graeme Smith is with the Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.), Ann E Sprague (0000-0001-8869-1181, Deshayne B. Fell, Ann E. Sprague, and Mark C. Walker are with Better Outcomes Registry & Network (BORN) Ontario and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Ning Liu is with the Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Abdool S. Yasseen III and Shi-Wu Wen are with the Ottawa Hospital Research Institute. Graeme Smith is with the Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.), Ning Liu (0000-0001-8399-8985, Deshayne B. Fell, Ann E. Sprague, and Mark C. Walker are with Better Outcomes Registry & Network (BORN) Ontario and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Ning Liu is with the Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Abdool S. Yasseen III and Shi-Wu Wen are with the Ottawa Hospital Research Institute. Graeme Smith is with the Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.), Abdool S Yasseen (0000-0001-9814-9249, Deshayne B. Fell, Ann E. Sprague, and Mark C. Walker are with Better Outcomes Registry & Network (BORN) Ontario and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Ning Liu is with the Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Abdool S. Yasseen III and Shi-Wu Wen are with the Ottawa Hospital Research Institute. Graeme Smith is with the Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.), Shi Wu Wen (0000-0002-7227-0283, Children's Hospital of Eastern Ontario), Shi-Wu Wen (Deshayne B. Fell, Ann E. Sprague, and Mark C. Walker are with Better Outcomes Registry & Network (BORN) Ontario and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Ning Liu is with the Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Abdool S. Yasseen III and Shi-Wu Wen are with the Ottawa Hospital Research Institute. Graeme Smith is with the Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.), Graeme N Smith (0000-0002-3128-4523, Children's Hospital of Eastern Ontario), Graeme Smith (0000-0002-9925-9199, Deshayne B. Fell, Ann E. Sprague, and Mark C. Walker are with Better Outcomes Registry & Network (BORN) Ontario and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Ning Liu is with the Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Abdool S. Yasseen III and Shi-Wu Wen are with the Ottawa Hospital Research Institute. Graeme Smith is with the Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.), Mark Walker (0000-0002-0507-1954, Children's Hospital of Eastern Ontario), Mark C Walker (Deshayne B. Fell, Ann E. Sprague, and Mark C. Walker are with Better Outcomes Registry & Network (BORN) Ontario and the Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Ning Liu is with the Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Abdool S. Yasseen III and Shi-Wu Wen are with the Ottawa Hospital Research Institute. Graeme Smith is with the Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada.)
Year2012
Volume102
Issue6
Pagese33-e40
Publication date2012-06-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2011.300606
PMID22515877
PMCIDPMC3483960
OpenAlexW2155995435
LanguageEN
Citations received4
References cited35

Objectives. We evaluated the relationship between maternal H1N1 vaccination and fetal and neonatal outcomes among singleton births during the 2009–2010 H1N1 pandemic. Methods. We used a population-based perinatal database in Ontario, Canada, to examine preterm birth (PTB), small-for-gestational-age (SGA) births, 5-minute Apgar score below 7, and fetal death via multivariable regression. We compared outcomes between women who did and did not receive an H1N1 vaccination during pregnancy. Results. Of the 55 570 mothers with a singleton birth, 23 340 (42.0%) received an H1N1 vaccination during pregnancy. Vaccinated mothers were less likely to have an SGA infant based on the 10th (adjusted risk ratio [RR] = 0.90; 95% confidence interval [CI] = 0.85, 0.96) and 3rd (adjusted RR = 0.81; 95% CI = 0.72, 0.92) growth percentiles; PTB at less than 32 weeks’ gestation (adjusted RR = 0.73; 95% CI = 0.58, 0.91) and fetal death (adjusted RR = 0.66; 95% CI = 0.47, 0.91) were also less likely among these women. Conclusions. Our results suggest that second- or third-trimester H1N1 vaccination was associated with improved fetal and neonatal outcomes during the recent pandemic. Our findings need to be confirmed in future studies with designs that can better overcome concerns regarding biased estimates of vaccine efficacy

Apgar score · Confidence interval · Coronavirus disease 2019 (COVID-19) · Disease · Environmental health · Fetus · Gestation · Gestational age · Obstetrics · Pandemic · Population · Pregnancy · Relative risk · Small for gestational age · Vaccination · COVID-19 Impact on Reproduction · Immunology · Influenza Virus Research Studies · Internal Medicine · Medicine · Vaccine Coverage and Hesitancy · Pediatrics

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