Total Duration of Breastfeeding, Vitamin D Supplementation, and Serum Levels of 25-Hydroxyvitamin D

Bibliographic Data

ID11033743
AuthorsDenise Darmawikarta (Denise Darmawikarta, Yang Chen, Gerald Lebovic, and Jonathan L. Maguire are with the Applied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada. Catherine S. Birken, Patricia C. Parkin, and Jonathon L. Maguire are with the Department of Pediatrics, Hospital for Sick Children, Toronto, and the Department of Pediatrics, University of Toronto.), Yang Chen (0000-0001-5943-3247, Denise Darmawikarta, Yang Chen, Gerald Lebovic, and Jonathan L. Maguire are with the Applied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada. Catherine S. Birken, Patricia C. Parkin, and Jonathon L. Maguire are with the Department of Pediatrics, Hospital for Sick Children, Toronto, and the Department of Pediatrics, University of Toronto.), Gerald Lebovic (0000-0003-3540-3339, Denise Darmawikarta, Yang Chen, Gerald Lebovic, and Jonathan L. Maguire are with the Applied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada. Catherine S. Birken, Patricia C. Parkin, and Jonathon L. Maguire are with the Department of Pediatrics, Hospital for Sick Children, Toronto, and the Department of Pediatrics, University of Toronto.), Catherine S Birken (0000-0003-0308-8645, Denise Darmawikarta, Yang Chen, Gerald Lebovic, and Jonathan L. Maguire are with the Applied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada. Catherine S. Birken, Patricia C. Parkin, and Jonathon L. Maguire are with the Department of Pediatrics, Hospital for Sick Children, Toronto, and the Department of Pediatrics, University of Toronto.), Patricia C Parkin (0000-0003-2935-7145, Denise Darmawikarta, Yang Chen, Gerald Lebovic, and Jonathan L. Maguire are with the Applied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada. Catherine S. Birken, Patricia C. Parkin, and Jonathon L. Maguire are with the Department of Pediatrics, Hospital for Sick Children, Toronto, and the Department of Pediatrics, University of Toronto.), Jonathon L Maguire (0000-0002-4083-8612, Denise Darmawikarta, Yang Chen, Gerald Lebovic, and Jonathan L. Maguire are with the Applied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada. Catherine S. Birken, Patricia C. Parkin, and Jonathon L. Maguire are with the Department of Pediatrics, Hospital for Sick Children, Toronto, and the Department of Pediatrics, University of Toronto.)
Year2016
Volume106
Issue4
Pages714-719
Publication date2016-04-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2015.303021
PMID26890167
OpenAlexW2279318460
LanguageEN
Citations received1
References cited31

Objectives. To determine the association between total breastfeeding duration and serum 25-hydroxyvitamin D (25-OHD) and to explore whether vitamin D supplementation influences this association. Methods. We conducted a cross-sectional study of healthy children between September 2011 and August 2013 through the TARGet Kids! primary health care research network. Of the 4533 eligible children, we included only the 2508 who had 25-OHD measured. We assessed adjusted associations of total breastfeeding duration (in months) with serum 25-OHD and in supplemented versus nonsupplemented children, with the odds of 25-OHD less than 20 nanograms per milliliter. Results. Each 1-month increase in total breastfeeding duration was associated with a 0.12 nanograms per milliliter lower median serum 25-OHD (95% confidence interval [CI] = –0.21 ng/mL, –0.02 ng/mL) among children who were not supplemented. The odds of serum 25-OHD less than 20 nanograms per milliliter increased by 6% (odds ratio [OR] = 1.06; 95% CI = 1.03, 1.10) for every 1-month increase in total breastfeeding duration among nonsupplemented children. The interaction between vitamin D supplementation, duration of breastfeeding, and median serum 25-OHD was statistically significant (P = .04). Conclusions. Breastfed children who were not supplemented, particularly those breastfed more than 1 year, appear to have lower vitamin D status. Vitamin D supplementation may mitigate this risk. These findings support recommendations for supplementation during breastfeeding of any duration

Breast feeding · Breastfeeding · Confidence interval · Liter · Odds ratio · Vitamin · Vitamin D and neurology · vitamin D deficiency · Breastfeeding Practices and Influences · Internal Medicine · Medicine · Nutritional Studies and Diet · Vitamin D Research Studies · Pediatrics