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Trends in Prepregnancy Cardiometabolic Health in Rural and Urban Areas in the United States, 2016–2023

Bibliographic Data

ID11033902
AuthorsHavisha Pedamallu (0000-0002-1753-1153, At the time of this study, Havisha Pedamallu and Tanvi Nayak were with the Feinberg School of Medicine, Northwestern University, Chicago, IL. Alexa A. Freedman is with the Department of Preventive Medicine, Division of Epidemiology, Feinberg School of Medicine, Northwestern University. Kartik K. Venkatesh is with the Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus. William A. Grobman is with the Department of Obstetrics and Gynecology, Warren Alpert Medical S), Tanvi Nayak (At the time of this study, Havisha Pedamallu and Tanvi Nayak were with the Feinberg School of Medicine, Northwestern University, Chicago, IL. Alexa A. Freedman is with the Department of Preventive Medicine, Division of Epidemiology, Feinberg School of Medicine, Northwestern University. Kartik K. Venkatesh is with the Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus. William A. Grobman is with the Department of Obstetrics and Gynecology, Warren Alpert Medical S), Alexa A Freedman (0000-0001-9745-7768, At the time of this study, Havisha Pedamallu and Tanvi Nayak were with the Feinberg School of Medicine, Northwestern University, Chicago, IL. Alexa A. Freedman is with the Department of Preventive Medicine, Division of Epidemiology, Feinberg School of Medicine, Northwestern University. Kartik K. Venkatesh is with the Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus. William A. Grobman is with the Department of Obstetrics and Gynecology, Warren Alpert Medical S), Kartik K Venkatesh (0000-0002-8043-556X, At the time of this study, Havisha Pedamallu and Tanvi Nayak were with the Feinberg School of Medicine, Northwestern University, Chicago, IL. Alexa A. Freedman is with the Department of Preventive Medicine, Division of Epidemiology, Feinberg School of Medicine, Northwestern University. Kartik K. Venkatesh is with the Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus. William A. Grobman is with the Department of Obstetrics and Gynecology, Warren Alpert Medical S), William A Grobman (0000-0002-3979-0738, At the time of this study, Havisha Pedamallu and Tanvi Nayak were with the Feinberg School of Medicine, Northwestern University, Chicago, IL. Alexa A. Freedman is with the Department of Preventive Medicine, Division of Epidemiology, Feinberg School of Medicine, Northwestern University. Kartik K. Venkatesh is with the Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus. William A. Grobman is with the Department of Obstetrics and Gynecology, Warren Alpert Medical S), Sadiya S Khan (0000-0003-0643-1859, At the time of this study, Havisha Pedamallu and Tanvi Nayak were with the Feinberg School of Medicine, Northwestern University, Chicago, IL. Alexa A. Freedman is with the Department of Preventive Medicine, Division of Epidemiology, Feinberg School of Medicine, Northwestern University. Kartik K. Venkatesh is with the Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus. William A. Grobman is with the Department of Obstetrics and Gynecology, Warren Alpert Medical S), Natalie A Cameron (0000-0002-0613-7580, At the time of this study, Havisha Pedamallu and Tanvi Nayak were with the Feinberg School of Medicine, Northwestern University, Chicago, IL. Alexa A. Freedman is with the Department of Preventive Medicine, Division of Epidemiology, Feinberg School of Medicine, Northwestern University. Kartik K. Venkatesh is with the Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus. William A. Grobman is with the Department of Obstetrics and Gynecology, Warren Alpert Medical S)
Year2025
Volume116
Issue3
Pagese1-e4
Publication date2025-10-30
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2025.308299
PMID41166662
OpenAlexW4415712418
LanguageEN
References cited11

Objectives. To describe differences in prepregnancy cardiometabolic health in the United States by urbanicity from 2016 to 2023. Methods. We included 29 087 432 pregnant individuals 15 to 44 years old with data in the Centers for Disease Control and Prevention Natality Files. We calculated age-standardized trends in prepregnancy cardiometabolic health from 2016 to 2023 by urbanicity using the cardiovascular–kidney–metabolic (CKM) staging system (stage 0 [no risk factors], stage 1 [overweight/obesity], and stage 2 [diabetes or hypertension]). We used prevalence ratios to compare annual prevalence by urbanicity. Results. From 2016 to 2023, the prevalence of prepregnancy CKM stage 0 decreased in rural and urban areas, whereas the prevalence of stages 1 and 2 increased. Specifically, stage 0 decreased from 41.5% (95% confidence interval [CI] = 41.4%, 41.7%) to 35.6% (95% CI = 35.4%, 35.7%) in rural areas and from 48.2% (95% CI = 48.1%, 48.3%) to 40.7% (95% CI = 40.6%, 40.7%) in urban areas. Prevalence ratios for stages 0 through 2 in 2016 were 0.86 (95% CI = 0.86, 0.87), 1.12 (95% CI = 1.11, 1.12), and 1.36 (95% CI = 1.34, 1.39), respectively, in rural relative to urban areas and remained stable over the study period. Conclusions. In this national sample, prepregnancy cardiometabolic health decreased from 2016 to 2023 in urban and rural communities and exhibited a persistent gap, with rural areas more severely affected. ( Am J Public Health. Published online ahead of print October 30, 2025:e1–e4. https://doi.org/10.2105/AJPH.2025.308299 )

Confidence interval · Cross-sectional study · Disease · Public health · Relative risk · Rural area · Rural health · Rural population · Cardiovascular Health and Risk Factors · Cardiovascular Issues in Pregnancy · Gestational Diabetes Research and Management

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