The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa
A prospective cohort study
Bibliographic Data
| ID | 11035013 |
|---|---|
| Authors | Timothy J Doyle (0000-0002-4501-9157, University of Minnesota), Wei Zheng (0000-0002-3339-5606, University of Minnesota), James R Cerhan (0000-0002-7482-178X, University of Minnesota), C P Hong (University of Minnesota), Thomas A Sellers (0000-0002-7832-0405, University of Iowa), Lawrence H Kushi (0000-0001-9136-1175, University of Iowa), Aaron R Folsom (0000-0003-2635-2699, University of Minnesota) |
| Year | 1997 |
| Volume | 87 |
| Issue | 7 |
| Pages | 1168-1176 |
| Publication date | 1997-07-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | American Journal of Public Health (JOURNAL) |
| Journal identifiers | ISSN: 0090-0036 • E-ISSN: 1541-0048 |
| Publisher | American Public Health Association (PUBLISHER • US) |
| DOI | 10.2105/ajph.87.7.1168 |
| PMID | 9240108 |
| OpenAlex | W2065925808 |
| Language | EN |
| Citations received | 4 |
| References cited | 33 |
OBJECTIVES: This study assessed the association of drinking water source and chlorination by-product exposure with cancer incidence. METHODS: A cohort of 28,237 Iowa women reported their drinking water source. Exposure to chlorination by-products was determined from statewide water quality data. RESULTS: In comparison with women who used municipal ground-water sources, women with municipal surface water sources were at an increased risk of colon cancer and all cancers combined. A clear dose-response relation was observed between four categories of increasing chloroform levels in finished drinking water and the risk of colon cancer and all cancers combined. The relative risks were 1.00, 1.06, 1.39, and 1.68 for colon cancer and 1.00, 1.04, 1.24, and 1.25 for total cancers. No consistent association with either water source or chloroform concentration was observed for other cancer sites. CONCLUSIONS: These results suggest that exposure to chlorination by-products in drinking water is associated with increased risk of colon cancer
Cancer · Cancer incidence · Cohort · Cohort study · Colorectal cancer · Confidence interval · Environmental health · Incidence (geometry) · Prospective cohort study · Relative risk · Water source · Carcinogens and Genotoxicity Assessment · Environmental Science · Fecal contamination and water quality · Internal Medicine · Medicine · Water Treatment and Disinfection
Evaluation of Drinking Water Disinfectant Byproducts Compliance Data as an Indirect Measure for Short-Term Exposure in Humans
Ingestion of Nitrate and Nitrite and Risk of Stomach and Other Digestive System Cancers in the Iowa Women’s Health Study
Science, Pollution, and Clean Drinking Water
Meta-analysis of studies on individual consumption of chlorinated drinking water and bladder cancer
| Citations per year | 0.15 |
|---|---|
| Citation span | 1999 - 2021 (23) |
| Highly cited | No |