Efficacy of Haemophilus influenzae type b conjugate vaccines and persistence of disease in disadvantaged populations. The Haemophilus Influenzae Study Group
Bibliographic Data
| ID | 11035162 |
|---|---|
| Authors | Hamid Jafari (0000-0001-7330-6500, National Center for Infectious Diseases), H S Jafari, William G Adams (0000-0002-5330-0010), Katherine A Robinson (0000-0001-9209-454X), Brian D Plikaytis, Jay D Wenger |
| Year | 1999 |
| Volume | 89 |
| Issue | 3 |
| Pages | 364-368 |
| Publication date | 1999-03-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | American Journal of Public Health (JOURNAL) |
| Journal identifiers | ISSN: 0090-0036 • E-ISSN: 1541-0048 |
| Publisher | American Public Health Association (PUBLISHER • US) |
| DOI | 10.2105/ajph.89.3.364 |
| PMID | 10076486 |
| OpenAlex | W2006486304 |
| Language | EN |
| Citations received | 2 |
| References cited | 19 |
OBJECTIVES: The purpose of this study was to evaluate the effectiveness of Haemophilus influenzae type b (Hib) conjugate vaccines among children aged 2 to 18 months and to determine risk factors for invasive Hib disease during a period of declining incidence (1991-1994). METHODS: A prospective population-based case-control study was conducted in a multistate US population of 15.5 million. A laboratory-based active surveillance system was used for case detection. RESULTS: In a multivariate analysis, having a single-parent mother (odds ratio [OR] = 4.3, 95% confidence interval [CI] = 1.2, 14.8) and household crowding (OR = 3.5, 95% CI = 1.03, 11.7) were risk factors for Hib disease independent of vaccination status. After adjustment for these risk factors, the protective efficacy of 2 or more Hib vaccine doses was 86% (95% CI = 16%, 98%). Among undervaccinated subjects, living with a smoker (P = .02) and several indicators of lower socioeconomic status were risk factors for Hib disease. CONCLUSIONS: Hib disease still occurs at low levels in the United States, predominantly in socioeconomically disadvantaged populations. Low immunization coverage may facilitate continuing transmission of Hib. Special efforts to achieve complete and timely immunization in disadvantaged populations are needed
Antibiotics · Biology · Conjugate vaccine · Environmental health · Epiglottitis · Haemophilus influenzae · Hib vaccine · Immunization · Incidence (geometry) · Odds ratio · Population · Socioeconomic status · Vaccination · Bacterial Infections and Vaccines · Demography · Immunology · Internal Medicine · Medicine · Pneumonia and Respiratory Infections · Virology and Viral Diseases · Pediatrics
| Unique citing works | 2 |
|---|---|
| Citations per year | 0,1 |
| Citation span | 2006 - 2007 (2) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |