World Trade Center (WTC) Exposures and Cardiometabolic Risk Among WTC Health Program General Responders

Bibliographic Data

ID11037159
AuthorsHelena Krasnov (0000-0003-0230-3112, Helena Krasnov, Pablo Knobel, Hsiao-Hsien Leon Hsu, Susan L. Teitelbaum, and Maayan Yitshak Sade are with the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Krupa Ambalal Patel is with the Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai. Mary Ann McLaughlin is with the Department of Cardiology, Icahn School of Medicine at Mount Sinai. Allan C. Just is with the Department of Epidemiology, Brown University School of Public Health, Provid), Krupa Ambalal Patel (Helena Krasnov, Pablo Knobel, Hsiao-Hsien Leon Hsu, Susan L. Teitelbaum, and Maayan Yitshak Sade are with the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Krupa Ambalal Patel is with the Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai. Mary Ann McLaughlin is with the Department of Cardiology, Icahn School of Medicine at Mount Sinai. Allan C. Just is with the Department of Epidemiology, Brown University School of Public Health, Provid), Pablo Knobel (0000-0001-6902-0286, Helena Krasnov, Pablo Knobel, Hsiao-Hsien Leon Hsu, Susan L. Teitelbaum, and Maayan Yitshak Sade are with the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Krupa Ambalal Patel is with the Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai. Mary Ann McLaughlin is with the Department of Cardiology, Icahn School of Medicine at Mount Sinai. Allan C. Just is with the Department of Epidemiology, Brown University School of Public Health, Provid), Hsiao-Hsien Leon Hsu (0000-0001-8704-197X, Helena Krasnov, Pablo Knobel, Hsiao-Hsien Leon Hsu, Susan L. Teitelbaum, and Maayan Yitshak Sade are with the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Krupa Ambalal Patel is with the Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai. Mary Ann McLaughlin is with the Department of Cardiology, Icahn School of Medicine at Mount Sinai. Allan C. Just is with the Department of Epidemiology, Brown University School of Public Health, Provid), Susan L Teitelbaum (0000-0002-2190-1575, Helena Krasnov, Pablo Knobel, Hsiao-Hsien Leon Hsu, Susan L. Teitelbaum, and Maayan Yitshak Sade are with the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Krupa Ambalal Patel is with the Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai. Mary Ann McLaughlin is with the Department of Cardiology, Icahn School of Medicine at Mount Sinai. Allan C. Just is with the Department of Epidemiology, Brown University School of Public Health, Provid), Mary Ann McLaughlin (Helena Krasnov, Pablo Knobel, Hsiao-Hsien Leon Hsu, Susan L. Teitelbaum, and Maayan Yitshak Sade are with the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Krupa Ambalal Patel is with the Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai. Mary Ann McLaughlin is with the Department of Cardiology, Icahn School of Medicine at Mount Sinai. Allan C. Just is with the Department of Epidemiology, Brown University School of Public Health, Provid), Allan C Just (0000-0003-4312-5957, Helena Krasnov, Pablo Knobel, Hsiao-Hsien Leon Hsu, Susan L. Teitelbaum, and Maayan Yitshak Sade are with the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Krupa Ambalal Patel is with the Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai. Mary Ann McLaughlin is with the Department of Cardiology, Icahn School of Medicine at Mount Sinai. Allan C. Just is with the Department of Epidemiology, Brown University School of Public Health, Provid), Maayan Yitshak Sade (Helena Krasnov, Pablo Knobel, Hsiao-Hsien Leon Hsu, Susan L. Teitelbaum, and Maayan Yitshak Sade are with the Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Krupa Ambalal Patel is with the Graduate Program in Public Health, Icahn School of Medicine at Mount Sinai. Mary Ann McLaughlin is with the Department of Cardiology, Icahn School of Medicine at Mount Sinai. Allan C. Just is with the Department of Epidemiology, Brown University School of Public Health, Provid), Maayan Yitshak‐Sade (0000-0003-4453-0401, Icahn School of Medicine at Mount Sinai)
Year2025
Volume115
Issue7
Pages1120-1128
Publication date2025-07-01
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2025.308079
PMID40373236
OpenAlexW4410390639
LanguageEN
Citations received1
References cited31

Objectives. To assess the association between World Trade Center (WTC) exposures, cardiometabolic diseases (CMDs), and trajectories of glucose and systolic blood pressure (SBP) among WTC Health Program general responders (WTHPGR). Methods. We included monitoring visits (2003–2021) of WTHPGR who participated in the operations in New York City after the September 11, 2001, attack (n = 47 795). The WTC Health Program assessed WTC exposures using questionnaires and measured trajectories during monitoring study visits; CMDs were self-reported. We assessed associations with CMDs (hazard ratios and their corresponding 95% confidence intervals [CIs]) using survival analyses. We assessed associations with trajectories (odds ratios and their corresponding 95% CIs) using logistic regressions. Results. Interquartile range (IQR) increases in the number of days on-site in the 9 months following the attack were associated with increased diabetes (1.057; 95% CI = 1.025, 1.089) and hypertension (1.035; 95% CI = 1.014, 1.057) risks. IQR increases in hours on-site during September 2001 were associated with worsening glucose (1.040; 95% CI = 1.017, 1.064) and SBP (1.006; 95% CI = 1.001, 1.010) trajectories. Conclusions. WTC exposures are associated with higher CMD risk and worsening cardiometabolic trajectories among WTHPGR. Public Health implications. Linking WTC exposures to emerging diseases is vital because of its impact on health care costs and treatment access among WTHPGR. ( Am J Public Health. 2025;115(7):1120–1128. https://doi.org/10.2105/AJPH.2025.308079 )

Confidence interval · Environmental health · Hazard ratio · Interquartile range · Odds ratio · Public health · World trade center · Demography · Injury Epidemiology and Prevention · Internal Medicine · Medicine · Occupational Health and Performance · Pregnancy-related medical research · Gerontology