The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women
Bibliographic Data
| ID | 11037341 |
|---|---|
| Authors | Anna Coutsoudis (0000-0002-9078-5037, University of KwaZulu-Natal), R A Bobat, Raziya Bobat (0000-0002-2313-594X, New York Psychoanalytic Society and Institute), H M Coovadia, Hoosen Coovadia (New York Psychoanalytic Society and Institute), Louise Kuhn (0000-0002-2305-8665, New York Psychoanalytic Society and Institute), Wei Yann Tsai (New York Psychoanalytic Society and Institute), Zena Stein (New York Psychoanalytic Society and Institute), Z A Stein |
| Year | 1995 |
| Volume | 85 |
| Issue | 8_Pt_1 |
| Pages | 1076-1081 |
| Publication date | 1995-08-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | American Journal of Public Health (JOURNAL) |
| Journal identifiers | ISSN: 0090-0036 • E-ISSN: 1541-0048 |
| Publisher | American Public Health Association (PUBLISHER • US) |
| DOI | 10.2105/ajph.85.8_pt_1.1076 |
| PMID | 7625499 |
| OpenAlex | W2100315807 |
| Language | EN |
| Citations received | 3 |
| References cited | 27 |
OBJECTIVE. The effects of vitamin A supplementation on morbidity of children born to human immunodeficiency virus (HIV)-infected women were evaluated in a population where vitamin A deficiency is not endemic. METHODS. A randomized, placebo-controlled trial of vitamin A supplementation was carried out in 118 offspring of HIV-infected women in Durban, South Africa. Those assigned to receive a supplement were given 50,000 IU of vitamin A at 1 and 3 months of age; 100,000 IU at 6 and 9 months; and 200,000 IU at 12 and 15 months. Morbidity in the past month was then recalled at each follow-up visit. Analysis was based on 806 child-months. RESULTS. Among all children, the supplemented group had lower overall morbidity than the placebo group (OR = 0.69; 95% confidence interval [CI] = 0.48, 0.99). Among the 85 children of known HIV status (28 infected, 57 uninfected), morbidity associated with diarrhea was significantly reduced in the supplemented infected children (OR = 0.51; 95% CI = 0.27, 0.99), whereas no effect of supplementation on diarrheal morbidity was noted among the uninfected children. CONCLUSION. In a population not generally vitamin A deficient, vitamin A supplementation for children of HIV-infected women appeared to be beneficial, reducing morbidity. The benefit was observed particularly for diarrhea among HIV-infected children
Biology · Confidence interval · Diarrhea · Environmental health · Offspring · Placebo · Population · Pregnancy · Randomized controlled trial · Retinol · Vitamin · Vitamin A deficiency · Vitamin D and neurology · Antioxidant Activity and Oxidative Stress · Folate and B Vitamins Research · Internal Medicine · Medicine · Retinoids in leukemia and cellular processes · Pediatrics
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Community-Based Interventions for Improving Perinatal and Neonatal Health Outcomes in Developing Countries
Vitamin A deficiency during pregnancy of HIV infected and non-infected women in tropical settings of Northwest Ethiopia
| Citations per year | 0.14 |
|---|---|
| Citation span | 2005 - 2011 (7) |
| Highly cited | No |