A decision-analytic approach to postexposure rabies prophylaxis

Bibliographic Data

ID11037859
AuthorsScott B Cantor (0000-0002-7072-6048, The University of Texas Medical Branch at Galveston), Richard D Clover (The University of Texas Medical Branch at Galveston), R F Thompson, Robert Thompson (0009-0009-2526-9616, The University of Texas Medical Branch at Galveston)
Year1994
Volume84
Issue7
Pages1144-1148
Publication date1994-07-01
Open AccessNo
TypeARTICLE
VenueAmerican Journal of Public Health (JOURNAL)
Journal identifiersISSN: 0090-0036 • E-ISSN: 1541-0048
PublisherAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.84.7.1144
PMID8017541
OpenAlexW2136449374
LanguageEN
Citations received6
References cited10

The risks and benefits of postexposure rabies prophylaxis were analyzed from clinical and economic perspectives. A decision-analytic model was constructed by using probability and outcome data from the literature and the state health department. Health outcomes were measured in quality-adjusted life years. In the base case (overweight adult male), treatment is optimal when the probability of animal rabidity is greater than 1 in 2000. Sensitivity analysis showed robustness in the treatment decision; however, the incremental cost-effectiveness ratio ($140,000/quality-adjusted life year) is sensitive to the rabidity probability. Treatment is optimal from the patient's perspective; however, it may not be cost-effective when the probability of rabidity is low

Cost effectiveness · Cost–benefit analysis · Decision analysis · Environmental health · Quality-adjusted life year · Rabies · Risk analysis (engineering) · Statistics · Autopsy Techniques and Outcomes · Data-Driven Disease Surveillance · Mathematics · Medicine · Rabies epidemiology and control · Virology

Tools

Open DOISci-Hub