The risk of chemical cocktail effects and how to deal with the issue
Bibliographic Data
| ID | 11171483 |
|---|---|
| Authors | Terje Svingen (0000-0003-4650-7651, Technical University of Denmark), Anne Marie Vinggaard (0000-0002-6822-3572, Technical University of Denmark, corresponding author) |
| Year | 2016 |
| Volume | 70 |
| Issue | 4 |
| Pages | 322-323 |
| Publication date | 2016-04-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech-2015-206268 |
| PMID | 26612875 |
| OpenAlex | W2288808341 |
| Language | EN |
| Citations received | 4 |
| References cited | 12 |
Background: Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor of childhood. It has been most commonly reported in the trunk, retroperitoneum, and extremities, but cases involving the head and neck have been described. While thought to have limited metastatic potential, it is associated with Kasabach-Merritt syndrome (KMS), a consumptive coagulopathy and profound thrombocytopenia that is associated with significant mortality. Twelve cases of KHE with bony involvement have previously been reported. Of these, only 2 involved the spine, and both were managed with medical therapy alone. Case Presentation: We report the first case of spinal KHE causing spinal cord compression managed with surgical excision presented in the literature to date. Conclusions: There are a number of treatment modalities outlined in the literature. The lack of a consensus is due to the varying methods of presentation, difficulty in diagnosis, and disease rarity. Our case highlights the potential speed of local growth of this tumor, meaning that excision may be a technical challenge, especially when there is epidural extension. Treating clinicians should be aware of the risk of progression beyond the initial tumor boundaries to involve new vertebrae
Coagulopathy · Consumptive Coagulopathy · Head and neck · Kasabach–Merritt syndrome · Presentation (obstetrics) · Trunk · Acute Lymphoblastic Leukemia research · Medicine · Renal and related cancers · Surgery · Vascular Malformations and Hemangiomas
| Citations per year | 0.44 |
|---|---|
| Citation span | 2017 - 2025 (9) |
| Highly cited | No |