Serum γ-glutamyltransferase
New insights about an old enzyme
Bibliographic Data
| ID | 11173155 |
|---|---|
| Authors | D-H Lee (Kyungpook National University), David R Jacobs (0000-0002-7232-0543, University of Minnesota) |
| Year | 2009 |
| Volume | 63 |
| Issue | 11 |
| Pages | 884-886 |
| Publication date | 2009-11-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech.2008.083592 |
| PMID | 19825792 |
| OpenAlex | W2151719687 |
| Language | EN |
| Citations received | 1 |
| References cited | 21 |
In recent prospective studies, serum γ-glutamyltransferase (GGT) within its normal range predicts various diseases with diverse pathophysiological processes. At present, the prevailing interpretation is that serum GGT is a marker of fatty liver or oxidative stress. However, serum GGT may predict many diseases as a cumulative biomarker of various environmental chemicals; cellular GGT is prerequisite for metabolism of glutathione (GSH) conjugates and GSH is a critical biomolecule for conjugation diverse chemicals. Supporting this concept, serum GGT within its normal range had clear dose–response associations with a variety of chemicals such as lead, cadmium, organochlorine pesticides, and dioxin. This idea is only at a beginning stage. If the associations of serum GGT with environmental chemicals were confirmed, it could have an enormous impact on public health because it would indicate that exposure to mixed chemicals at very low levels may not actually be safe
Biology · Biomarker · Enzyme · Gamma-glutamyltransferase · Glutathione · Oxidative stress · Xenobiotic · Alcohol Consumption and Health Effects · Biochemistry · Immunology · Internal Medicine · Medicine · Nutritional Studies and Diet · Physiology · Sulfur Compounds in Biology
| Citations per year | 0.14 |
|---|---|
| Citation span | 2019 - 2019 (1) |
| Highly cited | No |