Resting heart rate predicts incident myocardial infarction, atrial fibrillation, ischaemic stroke and death in the general population
The Tromsø Study
Bibliographic Data
| ID | 11174249 |
|---|---|
| Authors | Ekaterina Sharashova (0000-0001-9412-2065, UiT The Arctic University of Norway, corresponding author), Tom Wilsgaard (0000-0002-2709-9472, UiT The Arctic University of Norway), Ellisiv B Mathiesen (0000-0001-8887-6100, UiT The Arctic University of Norway), Maja-Lisa Løchen (UiT The Arctic University of Norway), Maja‐Lisa Løchen (0000-0002-8532-6573, UiT The Arctic University of Norway), Inger Njølstad (0000-0002-6391-231X, UiT The Arctic University of Norway), Tormod Brenn (0000-0003-3717-8323, UiT The Arctic University of Norway) |
| Year | 2016 |
| Volume | 70 |
| Issue | 9 |
| Pages | 902-909 |
| Publication date | 2016-09-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech-2015-206663 |
| PMID | 26951324 |
| OpenAlex | W2299686178 |
| Language | EN |
| References cited | 23 |
BACKGROUND: Elevated resting heart rate (RHR) increases risk of death overall, but a comprehensive picture of the associations between RHR, cardiovascular morbidity and mortality events has not yet been presented. We aimed to investigate the effect of RHR on the risk of 5 cardiovascular events: incident myocardial infarction (MI), incident atrial fibrillation (AF), incident ischaemic stroke, total death and cardiovascular death in a general population from Norway. METHODS: We followed 24 489 men and women from the Tromsø Study 1994-1995, a population-based cohort study, for 18 years, and analysed the association between RHR and the investigated cardiovascular events. Sex-specific Cox regression with time-dependent covariates was applied with the best-fitting fractional polynomials of RHR. RESULTS: Among men, an independent positive relationship was observed for MI and AF (adjusted HR for AF per 20 bpm increase=1.14; 95% CI 1.02 to 1.27). In women, the corresponding HR for MI was 1.23 (1.09 to 1.40). A J-shaped association was observed for ischaemic stroke in women when compared with a RHR of 70 bpm (HR for 50 bpm=1.31; 0.90 to 1.90; HR for 100 bpm=1.32; 1.04 to 1.69). Total and cardiovascular death showed a strong positive association with RHR in men. In women, the pattern for total death was similar. CONCLUSIONS: RHR is an independent risk factor for several cardiovascular events. A novel finding is the positive association between RHR and AF in men and the sex difference in association with ischaemic stroke
Atrial fibrillation · Blood pressure · Cardiology · Heart rate · Ischaemic heart disease · Ischaemic stroke · Myocardial infarction · Population · Stroke (engine) · Heart Failure Treatment and Management · Heart rate and cardiovascular health · Heart Rate Variability and Autonomic Control · Internal Medicine · Medicine
| Citation velocity | historical |
|---|---|
| Highly cited | No |