How polluted is your fat? What the study of adipose tissue can contribute to environmental epidemiology
Bibliographic Data
| ID | 11174451 |
|---|---|
| Authors | Vicente Mustieles (0000-0002-2010-5438, Universidad de Granada), Juan P Arrebola (0000-0002-8643-2423, CIBER Epidemiology and Public Health (CIBERESP), Spain, corresponding author) |
| Year | 2020 |
| Volume | 74 |
| Issue | 5 |
| Pages | 401-407 |
| Publication date | 2020-05-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech-2019-213181 |
| PMID | 32019765 |
| OpenAlex | W3005374402 |
| Language | EN |
| Citations received | 3 |
| References cited | 61 |
The study of the potential contribution of low-dose exposure to environmental chemicals on the development of chronic conditions in human populations is often hampered by methodological issues, including exposure misclassification and the inability to assess biological effects in target organs. White adipose tissue (WAT) presents the unique feature of being both an advantageous matrix for assessing long-term exposure to mixtures of persistent organic pollutants and an interesting tissue to investigate early preclinical effects. Moreover, other lipophilic non-persistent chemicals and heavy metals have been recently quantified in fat, suggesting that human WAT contains chemical mixtures more complex than initially thought. However, WAT has been scarcely used in environmental epidemiology due to collection difficulties. In this essay we discuss the potential of using human WAT as a source of both exposure and effect biomarkers, with the aim of advancing the epidemiological research of obesity-related diseases, including metabolic syndrome and cancer. Overall, we discuss the implications of investigating WAT in a multidisciplinary framework combining toxicological and epidemiological knowledge in order to improve the inference of causal relationships in observational settings. We finalise by suggesting feasible designs and scenarios in which WAT samples may be reasonably collected
Adipose tissue · Bioinformatics · Biology · Environmental epidemiology · Environmental health · Obesity · Observational study · Pathology · White adipose tissue · Air Quality and Health Impacts · Effects and risks of endocrine disrupting chemicals · Endocrinology · Epidemiology · Medicine · Per- and polyfluoroalkyl substances research
Perception and Demands of Pregnant and Breastfeeding Women Regarding Their Role as Participants in Environmental Research Studies
Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)
Interactions between environmental pollutants and dietary nutrients
Interpretation and identification of causal mediation.
A Dictionary of Epidemiology
New approaches to cope with possible harms of low-dose environmental chemicals
Education and health and well-being
Epigenetics and environmental exposures
Hormesis and public health
A multivariate approach to investigate the combined biological effects of multiple exposures
For a healthier future
SP1-47 Associations between Persistent Organic Pollutants (Pops) in visceral and subcutaneous adipose tissue and insulin resistance
| Citations per year | 0.6 |
|---|---|
| Citation span | 2021 - 2022 (2) |
| Highly cited | No |