Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies

Bibliographic Data

ID11178238
AuthorsCathrine Hoyo (0000-0002-2466-8617, Duke Medical Center, corresponding author), Susan K Murphy (0000-0001-8298-7272), Randy L Jirtle (0000-0003-1767-045X, Duke Medical Center)
Year2009
Volume63
Issue9
Pages683-684
Publication date2009-09-01
Open AccessNo
TypeARTICLE
VenueJournal of Epidemiology and Community Health (JOURNAL)
Journal identifiersISSN: 0143-005X • E-ISSN: 1470-2738
PublisherBMJ (PUBLISHER • GB)
DOI10.1136/jech.2009.090803
PMID19679714
PMCIDPMC3005185
OpenAlexW2105867212
LanguageEN
Citations received1
References cited25

In the etiologic investigation of complex diseases and neuro-developmental disorders, the interaction of genetic factors and the environment have been evaluated by comparing disease risk as a function of environmental exposure in individuals who carry genetic variants of interest. While advances in technology have improved classification of genetic variant data, methods to ascertain environmental exposures remain largely underdeveloped. In this editorial, we discuss how mitotically heritable epigenetic marks in imprint regulatory elements may potentially serve as genome-wide biosensors of exposure, thereby reducing exposure misclassification, especially in studies evaluating the early origins of adult disease. Development of epigenetic biosensors for exposure monitoring will require a concerted effort in not only demonstrating that they are a stable record of past exposures, but also that the epigenetic marks are causally related to exposure

Bioinformatics · Biology · Cognitive psychology · Disease · Environmental health · Epigenetics · Gene · Pathology · Recall · Epidemiology · Epigenetics and DNA Methylation · Folate and B Vitamins Research · Genetic Syndromes and Imprinting · Genetics · Medicine · Psychology

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