Self-reported sleep disturbance and incidence of dementia in ageing men
Bibliographic Data
| ID | 11178243 |
|---|---|
| Authors | Maria K Luojus (University of Eastern Finland, corresponding author), Soili M Lehto (0000-0003-4324-6679, University of Eastern Finland), Tommi Tolmunen (0000-0001-5359-4680, University of Eastern Finland), Anna-Katharine Brem (Max Planck Institute of Psychiatry), Anna‐Katharine Brem (0000-0003-0295-6834, Beth Israel Deaconess Medical Center), Eija Lönnroos (0000-0003-2672-2151, University of Eastern Finland), Jussi Kauhanen (0000-0003-1426-0199, University of Eastern Finland) |
| Year | 2017 |
| Volume | 71 |
| Issue | 4 |
| Pages | 329-335 |
| Publication date | 2017-04-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech-2016-207764 |
| PMID | 28275046 |
| OpenAlex | W2538275997 |
| Language | EN |
| Citations received | 2 |
| References cited | 51 |
Background Sleep disturbance is suggested to contribute to the development of dementia. However, prospective longitudinal data from middle-aged populations are scarce. Methods We investigated a population-based sample of 2386 men aged 42–62 years at baseline during 1984–1989. Participants having a history of mental illnesses, psychiatric medication, Parkinson's disease or dementia within 2 years after baseline (n=296) were excluded. Difficulty falling asleep or maintaining sleep, sleep duration and daytime tiredness were enquired. Dementia diagnoses (n=287) between 1984 and 2014 were obtained through linkage with hospital discharge, national death and special reimbursement registers. Cox proportional hazards analyses were performed for all dementias, and separately for Alzheimer's disease (n=234) and other phenotypes (n=53). Additional analyses were performed on a subsample of an apolipoprotein E ( APOE ) genotype-tested population (n=1199). Results The risk ratio for dementia was 1.58 (95% CI 1.10 to 2.27) in men with frequent sleep disturbance after adjustments for age, examination year, elevated depressive symptoms, physical activity, alcohol consumption, cumulative smoking history, systolic blood pressure, body mass index, low-density lipoprotein and high-density lipoprotein cholesterol, high-sensitivity C reactive protein, cardiovascular disease history, education years and living alone. Daytime tiredness and sleep duration were not associated with dementia in adjusted analysis. In the APOE subsample, both APOE ε4 genotype and frequent sleep disturbance were associated with increased dementia risk, but in the interaction analysis they had no joint effect. Conclusions Self-reported frequent sleep disturbance in middle-aged men may relate to the development of dementia in later life. Having an APOE ε4 genotype did not affect the relationship
Body mass index · Cognition · Dementia · Disease · Population · Proportional hazards model · Prospective cohort study · Psychiatry · Rotterdam Study · Sleep disorder · Dementia and Cognitive Impairment Research · Internal Medicine · Medicine · Sleep and related disorders · Sleep and Wakefulness Research · Gerontology
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| Unique citing works | 2 |
|---|---|
| Citations per year | 0,25 |
| Citation span | 2018 - 2024 (7) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 2 |