Diabetes, plasma glucose and incidence of colorectal cancer in Chinese adults

A prospective study of 0.5 million people

Bibliographic Data

ID11178561
AuthorsYuanjie Pang (0000-0002-4826-8861, University of Oxford), Christiana Kartsonaki (0000-0002-3981-3418, University of Oxford, corresponding author), Yu Guo (0009-0002-1747-4440, Chinese Academy of Medical Sciences, Beijing, China), Canqing Yu (0000-0002-0019-0014, Academy of Medical Sciences), Yiping Chen (0000-0002-4973-0296, University of Oxford), Ling Yang (0000-0001-5750-6588, University of Oxford), Zheng Bian (Chinese Academy of Medical Sciences, Beijing, China), Fiona Bragg (0000-0002-9181-6886, University of Oxford), Iona Y Millwood (0000-0002-0807-0682, University of Oxford), Leijia Shen (Tongxiang Renmin Hospital, Tongxiang, China), Songgen Zhou (Wuzhen Central Hospital, Tongxiang, China), Jiben Liu (Yongqing Road Community Health Center, Qingdao, China), Junshi Chen (0000-0001-5530-1343, National Center for Food Safety Risk Assessment, Beijing, China), Liming Li (0000-0001-5492-432X, Chinese Academy of Medical Sciences, Beijing, China), Michael V Holmes (0000-0001-6617-0879, University of Oxford), Zhengming Chen (0000-0001-9437-6452, University of Oxford)
Year2018
Volume72
Issue10
Pages919-925
Publication date2018-10-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Epidemiology and Community Health (JOURNAL)
Journal identifiersISSN: 0143-005X • E-ISSN: 1470-2738
PublisherBMJ (PUBLISHER • GB)
DOI10.1136/jech-2018-210651
PMID29970599
OpenAlexW2810886063
LanguageEN
References cited22

Background Diabetes is associated with higher risk of colorectal cancer (CRC). Uncertainty remains about the relevance of duration of diabetes and about the association of blood glucose with CRC risk among individuals without diabetes. Methods The prospective China Kadoorie Biobank recruited 512 713 participants in 2004–2008 from 10 diverse areas in China. After 10 years of follow-up, 3024 incident cases of CRC (1745 colon, 1716 rectal) were recorded among 510 136 participants without prior cancer at baseline. Cox regression was used to estimate adjusted HRs for CRC associated with diabetes (previously diagnosed or screen-detected) and, among those without previously diagnosed diabetes, with levels of random plasma glucose (RPG). Results Overall 5.8% of participants had diabetes at baseline. Individuals with diabetes had an adjusted HR of 1.18 (95% CI 1.04 to 1.33) for CRC, with similar risk for colon and rectal cancer (1.19 [1.01 to 1.39] vs 1.14 [0.96 to 1.35]). The HRs decreased with longer duration of diabetes ( p for trend 0.03). Among those without previously diagnosed diabetes, RPG was positively associated with CRC, with adjusted HRs per 1 mmol/L higher baseline RPG of 1.04 (1.02 to 1.05) for CRC, again similar for colon and rectal cancer (1.03 [1.01to 1.05] and 1.04 [1.02 to 1.06], respectively). The associations of diabetes and RPG appeared stronger in men than in women, but the differences were non-significant ( p for heterogeneity 0.3 and 0.2). Discussion Among Chinese adults, diabetes and higher blood glucose levels among those without known diabetes are associated with higher risk of CRC

Cancer · Cancer incidence · Colorectal cancer · Diabetes mellitus · Incidence (geometry) · Plasma glucose · Prospective cohort study · Cancer Risks and Factors · Endocrinology · Hyperglycemia and glycemic control in critically ill and hospitalized patients · Internal Medicine · Medicine · Metabolism, Diabetes, and Cancer · Oncology · Gerontology

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