Season of the first trimester of pregnancy predicts sensitisation to food allergens in childhood

A population-based cohort study from Finland

Bibliographic Data

ID11180798
AuthorsKaisa Pyrhönen (0000-0001-5455-5288, Lappeenranta-Lahti University of Technology, corresponding author), Esa Läärä (University of Oulu), Liisa Hiltunen (Oulu University Hospital), Minna Kaila (0000-0002-9645-4925, Tampere University Hospital), Timo T Hugg (0000-0003-2558-1780, University of Oulu), Timo Hugg, Simo Näyhä (0000-0002-2063-3118, Finnish Institute of Occupational Health)
Year2012
Volume66
Issue1
Pages49-56
Publication date2012-01-01
Peer ReviewedYes
Open AccessNo
TypeARTICLE
VenueJournal of Epidemiology and Community Health (JOURNAL)
Journal identifiersISSN: 0143-005X • E-ISSN: 1470-2738
PublisherBMJ (PUBLISHER • GB)
DOI10.1136/jech.2009.105411
PMID20959386
OpenAlexW2110984589
LanguageEN
Citations received1
References cited36

OBJECTIVE: To examine whether the season of birth or season of the early phase of gestation is associated with sensitisation to food allergens in children, with special reference to mothers' pollen exposure in spring. DESIGN: A population-based cohort study linking information from a questionnaire survey to allergy tests performed on the target population and regional pollen counts. POPULATION: Children born in 2001-6 who were resident in the province of South Karelia, Finland, at the time of the survey (N=5920). MAIN OUTCOME MEASURES: A positive result in any food allergy test or food-specific immunoglobulin E test (sIgE). RESULTS: The cumulative incidence of a positive food allergy test up to the age of 4 years was highest among children born in October-November (10%) and lowest among those born in June-July (5%), and correspondingly highest among children who were in their 11th gestational week in April-May (11%), the season of high concentrations of birch and alder pollen, and lowest among those reaching that stage in December-January (6%). The amplitude of seasonal variation in any test, estimated as the relative ratio between the peak and trough of the smoothed incidence curve over the year, was 2.03 (95% CI 1.52 to 2.76). The amplitudes of positive sIgE were especially pronounced for milk (3.07; 95% CI 1.81 to 5.50) and egg (3.03; 95% CI 1.86 to 5.18). CONCLUSIONS: Children having their early gestational period in the pollen season for broad-leafed trees are more prone to sensitisation to food allergens than other children

Allergy · Biology · Cohort · Cohort study · Environmental health · Food allergy · Gestation · Incidence (geometry) · Population · Pregnancy · Allergic Rhinitis and Sensitization · Asthma and respiratory diseases · Demography · Food Allergy and Anaphylaxis Research · Immunology · Internal Medicine · Medicine · Pediatrics

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