SP6-10 Procalcitonin and WBC, ESR, CRP alterations in children with systemic inflammatory response syndrome before and after treatment

Introduction Systemic inflammatory response syndrome (SIRS) due to infection is an important cause of morbidity and mortality in children. The present prospective observational study aimed to determine correlation between Procalcitonin (PCT) and WBC, ESR and C-reactive protein in toddlers before and after treatment. Methods Overall, 50 patients aged 1–36 months who were hospitalised at the Paediatrics Ward in Besat Hospital in Sanansaj city western Iran through a census sampling method were recruited. CBC was measured via cell counter; ESR by Westergren method, CRP via semi quantitative method and PCT via semi quantitative immunochromatography method. Pearson correlation coefficient was used to estimate correlation between WBC, ESR, CRP and PCT before and after treatment of SIRS. Results Correlation coefficients between PCT and CRP were determined as “Good” and between PCT and ESR was determined as “Mean” in the first day of trial before treatment was started. However, there was no significant correlation between PCT and WBC. In third day of treatment, no significant correlation was found between PCT and WBC count, ESR, CRP. Conclusions In the onset of treatment and for confirming the diagnosis of SIRS, Procalcitonin and CRP are more favourable values. PCT would be more useful marker to be considered for fallow up procedures

C-reactive protein · Inflammation · Inflammatory response · Procalcitonin · Prospective cohort study · Sepsis · Systemic inflammatory response syndrome · Gastroenterology · Internal Medicine · Medicine · Sepsis Diagnosis and Treatment