Two Types of Ovidian Personification
Bibliographic Data
| ID | 11743140 |
|---|---|
| Authors | Arum Park (0000-0001-7415-8220, corresponding author) |
| Year | 2009 |
| Volume | 104 |
| Issue | 3 |
| Pages | 225-240 |
| Publication date | 2009-01-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | The Classical Journal (JOURNAL) |
| Journal identifiers | ISSN: 0009-8353 • E-ISSN: 2327-5812 |
| Publisher | Classical Association of the Middle West and South (PUBLISHER • US) |
| DOI | 10.1353/tcj.2009.0014 |
| OpenAlex | W19050858 |
| Language | EN |
| Citations received | 2 |
Ischemia-induced cerebral injury evolves over a longer period than previously believed through post-ischemic inflammation. Retinoic acid (RA) has been shown to exert cytoprotective effects on several cells, but its effects on ischemia-induced cerebral injury have been poorly characterized. The aim of the present study was to examine the effects of all-trans-RA on ischemia-induced cerebral injury and elucidate the underlying mechanism. All-trans-RA treatment reduced the size of the ischemia-induced cerebral infarct. To elucidate the underlying mechanism, ischemia-induced cerebral inflammation was studied by examination of expressions of interleukin 1beta (IL-1beta) and ED-1. RA treatment significantly reduced the cerebral inflammation. Moreover, cerebral ischemic induction of cyclooxygenase-2 (COX-2) and CCAAT/enhancer binding protein beta (C/EBPbeta), which binds to the COX-2 promoter, was also inhibited by RA. These results suggest that RA can reduce ischemia-induced cerebral injury by an anti-inflammatory action, which may be effected via inhibition of C/EBPbeta-mediated COX-2 induction
| Citations per year | 0.33 |
|---|---|
| Citation span | 2020 - 2021 (2) |
| Highly cited | No |