DeamiDate 1.0
Site-specific deamidation as a tool to assess authenticity of members of ancient proteomes
Dados Bibliográficos
| ID | 11900682 |
|---|---|
| Autores | Abigail Ramsøe (0000-0001-5132-007X, Natural History Museum, autor correspondente), Vivian van Heekeren (University of York), Paola Ponce (0000-0001-8568-5210, University of York), Román Fischer (0000-0002-9715-5951, University of Oxford), Ian Barnes (0000-0001-8322-6918, Natural History Museum), Camilla Speller (0000-0001-7128-9903, University of British Columbia), M J Collins (0000-0003-4226-5501, University of Copenhagen) |
| Ano | 2020 |
| Volume | 115 |
| Páginas | 105080-105080 |
| Data de publicação | 2020-01-26 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Journal of Archaeological Science (JOURNAL) |
| Identificadores do periódico | ISSN: 0305-4403 • E-ISSN: 1095-9238 |
| Editora | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jas.2020.105080 |
| OpenAlex | W3002060585 |
| Idioma | EN |
| Citações recebidas | 15 |
| Referências citadas | 55 |
Contamination is a potential problem in the study of ancient proteins, either from prior handling of the sample, laboratory consumables, or cross-sample carryover from mass spectrometers. Recently, deamidation of glutamine has been proposed as a measure for assessing the degradation of ancient proteins. Here, we present deamiDATE 1.0, a method for the authentication of ancient proteins using measure of site-specific deamidation rates. We test this approach on shotgun proteomic data derived from bone collagen from modern, archaeological and extinct taxa. We further demonstrate how this method may be used to differentiate between modern contaminants and authentic ancient proteins using a case study from Neolithic dental calculus
Ancient DNA · Archaeology · Biology · Chromatography · Computational biology · Deamidation · Geography · Proteome · Sample (material · Archaeology and ancient environmental studies · Chemistry · Forensic and Genetic Research · Forensic Anthropology and Bioarchaeology Studies · Medicine · Biochemistry
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| Obras citantes distintas | 15 |
|---|---|
| Citações por ano | 2,5 |
| Intervalo de citações | 2020 - 2026 (7) |
| Velocidade de citação | current |
| Altamente citado | Não |
| Tipos de citação | Neutras: 14 |