Thinking in 3 dimensions
Philosophies of the microenvironment in organoids and organs-on-chip
Bibliographic Data
| ID | 12028879 |
|---|---|
| Authors | Silvia Caianiello (0000-0002-7573-088X, Stazione Zoologica Anton Dohrn, corresponding author), Marta Bertolaso (0000-0003-2241-7029, Università Campus Bio-Medico), Guglielmo Militello (0000-0003-2657-3977, Università Campus Bio-Medico) |
| Year | 2023 |
| Volume | 45 |
| Issue | 2 |
| Pages | 14-14 |
| Publication date | 2023-03-22 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | History & Philosophy of the Life Sciences (JOURNAL) |
| Journal identifiers | ISSN: 0391-9714 • E-ISSN: 1742-6316 |
| Publisher | Springer Nature (PUBLISHER • SG) |
| DOI | 10.1007/s40656-023-00560-z |
| PMID | 36949354 |
| OpenAlex | W4353041350 |
| Language | EN |
| Citations received | 2 |
| References cited | 180 |
Organoids and organs-on-a-chip are currently the two major families of 3D advanced organotypic in vitro culture systems, aimed at reconstituting miniaturized models of physiological and pathological states of human organs. Both share the tenets of the so-called "three-dimensional thinking", a Systems Physiology approach focused on recapitulating the dynamic interactions between cells and their microenvironment. We first review the arguments underlying the "paradigm shift" toward three-dimensional thinking in the in vitro culture community. Then, through a historically informed account of the technical affordances and the epistemic commitments of these two approaches, we highlight how they embody two distinct experimental cultures. We finally argue that the current systematic effort for their integration requires not only innovative "synergistic" engineering solutions, but also conceptual integration between different perspectives on biological causality
Affordance · Biology · Cognition · Cognitive science · Conceptual Blending · Engineering ethics · Epistemology · Human–computer interaction · Nanotechnology · Organ-on-a-chip · Organoid · Sociology · Systems thinking · 3D Printing in Biomedical Research · Cell Image Analysis Techniques · Computer Science · Engineering · Neuroscience · Philosophy · Pluripotent Stem Cells Research · Psychology · Ecology
| Unique citing works | 2 |
|---|---|
| Citations per year | 2 |
| Citation span | 2026 - 2026 (1) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 1 |