The Northern Ireland human rights commission
Bibliographic Data
| ID | 12112286 |
|---|---|
| Authors | Stephen J Livingstone (0000-0002-7240-5037, Queen's University Belfast, corresponding author), Stephen Livingstone |
| Year | 2000 |
| Volume | 15 |
| Issue | 1 |
| Pages | 163-171 |
| Publication date | 2000-01-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Irish Political Studies (JOURNAL) |
| Journal identifiers | ISSN: 0790-7184 • E-ISSN: 1743-9078 |
| Publisher | Routledge (PUBLISHER • GB) |
| DOI | 10.1080/07907180008406621 |
| OpenAlex | W37894458 |
| Language | EN |
| Citations received | 4 |
This study aims to combine computed tomography (CT)-based texture analysis (QTA) and a microbiome-based biomarker signature to predict the overall survival (OS) of immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients by analyzing their CT scans ( n = 129) and fecal microbiome ( n = 58). One hundred and five continuous CT parameters were obtained, where principal component analysis (PCA) identified seven major components that explained 80% of the data variation. Shotgun metagenomics (MG) and ITS analysis were performed to reveal the abundance of bacterial and fungal species. The relative abundance of Bacteroides dorei and Parabacteroides distasonis was associated with long OS (>6 mo), whereas the bacteria Clostridium perfringens and Enterococcus faecium and the fungal taxa Cortinarius davemallochii, Helotiales, Chaetosphaeriales, and Tremellomycetes were associated with short OS (≤6 mo). Hymenoscyphus immutabilis and Clavulinopsis fusiformis were more abundant in patients with high (≥50%) PD-L1-expressing tumors, whereas Thelephoraceae and Lachnospiraceae bacterium were enriched in patients with ICI-related toxicities. An artificial intelligence (AI) approach based on extreme gradient boosting evaluated the associations between the outcomes and various clinicopathological parameters. AI identified MG signatures for patients with a favorable ICI response and high PD-L1 expression, with 84% and 79% accuracy, respectively. The combination of QTA parameters and MG had a positive predictive value of 90% for both therapeutic response and OS. According to our hypothesis, the QTA parameters and gut microbiome signatures can predict OS, the response to therapy, the PD-L1 expression, and toxicity in NSCLC patients treated with ICI, and a machine learning approach can combine these variables to create a reliable predictive model, as we suggest in this research
Commission · Ethnology · Fundamental rights · Human rights · International human rights law · Legislation · Linguistic rights · Northern ireland · Political science · Right to property · Sociology · State (computer science · European and International Law Studies · European Criminal Justice and Data Protection · Law · Ombudsman and Human Rights · Public Administration
| Citations per year | 0.27 |
|---|---|
| Citation span | 2011 - 2022 (12) |
| Highly cited | No |