Genotypes and Phenotypes in the Evolution of Molecules
Bibliographic Data
| ID | 12418167 |
|---|---|
| Authors | Peter Schuster (0000-0002-2253-8827, Santa Fe Institute, corresponding author) |
| Year | 2009 |
| Volume | 17 |
| Issue | 2 |
| Pages | 281-319 |
| Publication date | 2009-04-28 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | European Review (JOURNAL) |
| Journal identifiers | ISSN: 1062-7987 • E-ISSN: 1474-0575 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1062798709000787 |
| OpenAlex | W2035351093 |
| Language | EN |
| References cited | 105 |
Genotypes are DNA or RNA sequences that -together with epigenetic and environmental influences -determine the unfolding of the phenotype. Commonly, this process is extremely complicated and -at least for the time being -escapes rigorous mathematical analysis and serious computer modeling. Nevertheless, the relations between genotypes and phenotypes play a fundamental role in biology and in its applications to pharmaceutical research and medicine. In particular, many questions concerning evolution and its mechanisms cannot be answered without an understanding of the phenotypic consequences of changes in the genotypes. Neglecting epigenetics and environmental change for the moment, genotypes and phenotypes play clearly defined distinct parts in Darwinian evolution, which is understood as the interplay of variation and selection: all variations, mutations, recombination, and gene duplication, are changes in the polynucleotide sequences of the genotype whereas the phenotype is the target of selection
Action (physics · Biology · Content (measure theory · Gene · Genotype · Phenotype · Physics · Evolution and Genetic Dynamics · Mathematics · Origins and Evolution of Life · RNA and protein synthesis mechanisms · Genetics
| Highly cited | No |
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