Racial/ethnic variation in the prevalence of vaccine-related human papillomavirus genotypes

Bibliographic Data

ID12554332
AuthorsJane R Montealegre (0000-0002-0840-9316, Baylor College of Medicine, corresponding author), Indu Varier (0000-0001-5163-0019, Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA), Christina Bracamontes (0000-0001-5247-1937, Texas Tech University Health Sciences Center), Christina G Bracamontes (Department of Obstetrics and Gynecology, Texas Tech Health Sciences Center, El Paso, TX, USA), Laura M Dillon (0009-0005-1540-0431, Department of Diagnostic and Biomedical Sciences, University of Texas School of Dentistry, Houston, TX, USA), Martial Guillaud (0000-0001-8982-2489, Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada), Andrew G Sikora (0000-0002-8357-8435, Baylor College of Medicine), Michele Follen (0000-0001-9628-9475, Brookdale University Hospital and Medical Center), Karen Adler‐Storthz, Karen Adler-Storthz (Department of Diagnostic and Biomedical Sciences, University of Texas School of Dentistry, Houston, TX, USA), Michael E Scheurer (0000-0002-8379-6088, Baylor College of Medicine)
Year2017
Volume24
Issue7
Pages804-815
Publication date2017-09-04
Open AccessNo
TypeARTICLE
VenueEthnicity and Health (JOURNAL)
Journal identifiersISSN: 1355-7858 • E-ISSN: 1465-3419
PublisherTaylor & Francis (PUBLISHER • GB)
DOI10.1080/13557858.2017.1373073
PMID28870103
OpenAlexW2753319306
LanguageEN
References cited23

Objective: There are currently three licensed human papillomavirus (HPV) vaccines that protect against cervical cancer. Here we compare the prevalence of bi-, quadri-, and nonavalent vaccine-related HPV genotypes in a multi-ethnic sample of non-Hispanic white, non-Hispanic black, Hispanic, and Asian women. Design: Patients in this analysis ( n = 419) represent a subset of women with a previous abnormal Pap test participating in a clinical trial. HPV genotyping was conducted using the Roche Linear Array. Prevalent HPV genotypes were grouped according to their inclusion in each of the vaccines: bivalent (16, 18), quadrivalent (16, 18, 6, 11), and nonavalent (16, 18, 31, 33, 45, 52, 58, 6, 11). Results: The prevalence of HPV genotypes covered by the bi-/quadrivalent vaccines was lowest among non-Hispanic black (15%) and Hispanic women (20%), compared to non-Hispanic white (38%) and Asian women (38%). Across all racial/ethnic groups, a large proportion of infections (38%-49%) were with genotypes included in the nonavalent vaccine. However, the prevalence of HPV genotypes not covered by any vaccine was significantly higher among non-Hispanic black (36%) and Hispanic women (42%), compared to non-Hispanic white (24%) and Asian women (16%) ( p Conclusion: Our data suggest racial/ethnic differences in the prevalence of vaccine-related HPV genotypes. In particular, non-Hispanic black and Hispanic women had the lowest prevalence of HPV genotypes covered by the bi-/quadrivalent vaccines. While a large proportion of their infections were covered by the nonavalent vaccine, non-Hispanic black and Hispanic women also had the highest prevalence of HPV genotypes not covered by any vaccine

Biology · Cancer · Cervical cancer · Ethnic group · Gardasil · Gene · Genetic variation · Genotype · Human papillomavirus · Human papillomavirus vaccine · Sociology · Variation (astronomy · Anthropology · Cervical Cancer and HPV Research · Cholangiocarcinoma and Gallbladder Cancer Studies · Demography · Hepatitis B Virus Studies · Medicine · Genetics · Internal Medicine · Virology

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