Effect of dolutegravir-based regimen on the body mass index of adolescents living with HIV in an African population
A pre-post design
Bibliographic Data
| ID | 12893968 |
|---|---|
| Authors | Ifeyinwa L Ezenwosu (0000-0001-5235-292X, University of Nigeria Teaching Hospital, corresponding author), Justus Uchenna Onu (0000-0002-4567-7096, Nnamdi Azikiwe University), Uchenna V Chukwuma (University of Nigeria Teaching Hospital), Chinwe Chukwuka (University of Nigeria Teaching Hospital) |
| Year | 2024 |
| Volume | 19 |
| Issue | 3 |
| Pages | 609-618 |
| Publication date | 2024-04-19 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Vulnerable Children and Youth Studies (JOURNAL) |
| Journal identifiers | ISSN: 1745-0136 • E-ISSN: 1745-0128 |
| Publisher | Routledge (PUBLISHER • GB) |
| DOI | 10.1080/17450128.2024.2343589 |
| OpenAlex | W4394961825 |
| Language | EN |
| References cited | 21 |
Dolutegravir, an integrase strand inhibitor, has been linked to an increase in body mass index among adults. However, little is known about its effect on adolescents. The study assessed the effect of a dolutegravir-based regimen on adolescents' body weight and emphasized the gender-specific differences in weight gain, if any. This prospective cohort study was conducted among 182 treatment-experienced adolescents living with HIV at a tertiary hospital in Southeast Nigeria. The body mass index measurements were calculated before transitioning to dolutegravir and after six months of being on the dolutegravir regimen. A comparison of the difference in mean body mass index before and after dolutegravir-based therapy was determined using a paired t-test. At the end of the six-month follow-up, there was a significant increase in the respondents' overall body mass index z-score (t = −10.00, p < 0.001). There was a significant increase in the body mass index z-score of both genders (male; t = −7.49, p < 0.001, female; t = −6.91, p < 0.001). The dolutegravir-based therapy (β-coefficient = −0.17, t = − 2.09, p < 0.001) and baseline body mass index z-score (β-coefficient = 0.76, t = 15.86, p < 0.001) were significant predictors of body mass index z-score at six months. In adolescents living with HIV, the transition to dolutegravir is associated with increased body weight. Female adolescents tend to gain more weight compared to males. Therefore, there is a need for regular monitoring of body weight for early detection of obesity and prompt intervention
Antiretroviral therapy · Body mass index · Dolutegravir · Environmental health · Human immunodeficiency virus (HIV · Index (typography · Population · Regimen · Viral load · Computer Science · Diabetes and associated disorders · HIV-related health complications and treatments · Liver Disease Diagnosis and Treatment · Medicine · Gerontology · Internal Medicine · Virology
| Highly cited | No |
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