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A decision analytic model to guide early‐stage government regulatory action

Applications for synthetic biology

Bibliographic Data

ID12899665
AuthorsBenjamin D Trump (0000-0002-4097-733X, corresponding author), Christopher L Cummings (0000-0002-3840-556X), Jennifer Kuzma (0000-0003-4456-9613), Igor Linkov (0000-0002-0823-8107)
Year2017
Volume12
Issue1
Pages88-100
Publication date2017-02-27
Open AccessYes
TypeARTICLE
VenueRegulation & Governance (JOURNAL)
Journal identifiersISSN: 1748-5983 • E-ISSN: 1748-5991
PublisherWiley (PUBLISHER • GB)
DOI10.1111/rego.12142
OpenAlexW2594713822
LanguageEN
Citations received3
References cited25

Synthetic biology (SB) involves the alteration of living cells and biomolecules for specific purposes. Products developed using these approaches could have significant societal benefits, but also pose uncertain risks to human and environmental health. Policymakers currently face decisions regarding how stringently to regulate and monitor various SB applications. This is a complex task, in which policymakers must balance uncertain economic, political, social, and health‐related decision factors associated with SB use. We argue that formal decision analytical tools could serve as a method to integrate available evidence‐based information and expert judgment on the impacts associated with SB innovations, synthesize that information into quantitative indicators, and serve as the first step toward guiding governance of these emerging technologies. For this paper, we apply multi‐criteria decision analysis to a specific case of SB, a micro‐robot based on biological cells called “cyberplasm.” We use data from a Delphi study to assess cyberplasm governance options and demonstrate how such decision tools may be used for assessments of SB oversight

Action (physics · Action plan · Biology · Business · Corporate governance · Economics · Government (linguistics · Management science · Political science · Politics · Precautionary principle · Risk analysis (engineering · Computer Science · Gene Regulatory Network Analysis · Sustainability and Climate Change Governance · Biotechnology

  • Gobernanza de los riesgos de tecnologías emergentes

    Open Access•César Cisternas Irarrázabal, Arturo Vallejos Romero et al.•Sociología y tecnociencia•2025

  • Synthetic biology and governance research in China

    Open Access•Li Tang, Jennifer Kuzma et al.•Scientometrics•2023

  • Regulation and regime

    Open Access•Scott L Greer, Benjamin D Trump et al.•Policy Sciences•2019

  • Qualitative Research

    Open Access•Michael Quinn Patton•Encyclopedia of statistics in…•2005

  • Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

    Open Access•Daniel G Gibson, John I Glass et al.•Science•2010

  • Unpackaging synthetic biology

    Open Access•Jennifer Kuzma, Todd Tanji•Regulation & Governance•2010

Citations per year0.43
Citation span2019 - 2025 (7)
Highly citedNo

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Open DOISci-HubOpen Access
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