Eye Movement Performance and Prefrontal Hemodynamics during Saccadic Eye Movements in the Elderly
Bibliographic Data
| ID | 12963648 |
|---|---|
| Authors | Katsuo Fujiwara (Kanazawa University, corresponding author), Naoe Kiyota (Kanazawa University), Kenji Kunita (Sapporo International University), Midori Yasukawa (Kanazawa University), Kaoru Maeda (Morinomiya University of Medical Sciences), Xingyun Deng (Kanazawa University) |
| Year | 2010 |
| Volume | 29 |
| Issue | 2 |
| Pages | 71-78 |
| Publication date | 2010-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of PHYSIOLOGICAL ANTHROPOLOGY (JOURNAL) |
| Journal identifiers | ISSN: 1880-6791 • E-ISSN: 1880-6805 |
| Publisher | BioMed Central (PUBLISHER • GB) |
| DOI | 10.2114/jpa2.29.71 |
| PMID | 20551587 |
| OpenAlex | W2039980901 |
| Language | EN |
| References cited | 33 |
No previous study has investigated age-related changes in prefrontal hemodynamics during saccade tasks in a large number of elderly adults. The purpose of this study was to evaluate prefrontal activity related to the performance of anti-saccade in the elderly using near-infrared spectroscopy (NIRS). Ninety-six elderly adults and 22 young adults performed pro- and anti-saccade tasks. Measures included reaction times of both saccades, error rate during anti-saccade, and concentration of oxyhemoglobin (Deltaoxy-Hb) in the prefrontal cortex during both saccades. Saccade performance, especially error rate, was significantly poorer in the elderly than the young. In the elderly, error rates were widely distributed from 5% to 100%. In about half (48%) of the elderly, error rates were distributed under the mean+3 standard deviations (48%) for the young, and Deltaoxy-Hb did not differ significantly from that in the young. Elderly subjects whose anti-saccade reaction time was over the regression line (of reaction time in anti-saccade to that in pro-saccade in the young)+2 standard errors showed a strong positive correlation (r=0.79) between Deltaoxy-Hb and error rate, as did those whose error rate exceeded 48%. In the elderly subjects whose error rates exceeded 90%, Deltaoxy-Hb was extremely small and deviated greatly from the correlation between Deltaoxy-Hb and error rate. Based on these findings, we propose a method of evaluating inhibitory function and attention allocation in anti-saccade performance, which is mainly related to the prefrontal cortex, in the elderly, using NIRS
Audiology · Cognition · Eye movement · Prefrontal cortex · Saccade · Saccadic masking · Glaucoma and retinal disorders · Medicine · Neuroscience · Optical Imaging and Spectroscopy Techniques · Psychology · Visual perception and processing mechanisms
| Highly cited | No |
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