Inflammaging” and Estradiol among Older U.S. Women
A Nationally Representative Longitudinal Study
Bibliographic Data
| ID | 12986709 |
|---|---|
| Authors | Aniruddha Das (0000-0002-1338-2971, McGill University, corresponding author) |
| Year | 2017 |
| Volume | 63 |
| Issue | 4 |
| Pages | 295-308 |
| Publication date | 2017-10-02 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Biodemography and Social Biology (JOURNAL) |
| Journal identifiers | ISSN: 1948-5565 • E-ISSN: 1948-5573 |
| Publisher | Taylor & Francis (PUBLISHER • GB) |
| DOI | 10.1080/19485565.2017.1403304 |
| PMID | 29199869 |
| OpenAlex | W2775069330 |
| Language | EN |
| References cited | 49 |
Despite accumulating small-sample and clinical evidence on "inflammaging," no population-representative longitudinal studies have specifically examined women's late-life inflammation trends. While a range of studies indicates estradiol's immunomodulation role, evidence is contradictory on whether its effects are pro- or antiinflammatory among older women. Using longitudinal data from the first two waves of the National Social Life, Health and Aging Project-a national probability sample of older U.S. adults aged 57 to 85 years at baseline-this study began to fill these gaps. Findings suggested rather than being a lifelong process, older women's inflammaging may have a biological window that closes with senescence. Moreover, their endogenous estradiol plays a proinflammatory rather than immunoprotective role. Nor does this sex steroid modulate age effects on women's inflammation. More sex-specific basic research is needed on causal mechanisms underlying women's late-life inflammaging patterns
Ageing · Health and Retirement Study · Longitudinal data · Longitudinal study · Population · Senescence · Sociology · Window of opportunity · Demography · Gender Roles and Identity Studies · Medicine · Menopause: Health Impacts and Treatments · Psychology · Sex and Gender in Healthcare · Gerontology · Internal Medicine
Sex differences in immune responses
Social relationships and physiological determinants of longevity across the human life span
Markers of Inflammation and Cardiovascular Disease
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
High-Sensitivity Enzyme Immunoassay for C-Reactive Protein in Dried Blood Spots
Accounting for Bias Due to Selective Attrition
Sample Design, Sample Augmentation, and Estimation for Wave 2 of the NSHAP
The Utility and Dynamics of Salivary Sex Hormone Measurements in the National Social Life, Health, and Aging Project, Wave 2
Survey Field Methods for Expanded Biospecimen and Biomeasure Collection in NSHAP Wave 2
Medication Data Collection and Coding in a Home-Based Survey of Older Adults
The Use of Dried Blood Spot Sampling in the National Social Life, Health, and Aging Project
Change Scores as Dependent Variables in Regression Analysis
Validation of Blood-Based Assays Using Dried Blood Spots for Use in Large Population Studies
Psychosocial distress and inflammation
Social Inequalities in Happiness in the United States, 1972 to 2004
The Ecologies of Human Immune Function
| Citation velocity | historical |
|---|---|
| Highly cited | No |