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Microplastic and nanoplastic pollution and associated potential disease risks

Bibliographic Data

ID13123673
AuthorsNurshad Ali (0000-0003-1649-0887, corresponding author), Jenny Katsouli, Eric Auyang (0009-0005-3024-2881, Imperial College London), Jorge Bernardino de la Serna (0000-0002-1396-3338)
Year2025
Volume9
Issue12
Pages101390-101390
Publication date2025-12-01
Open AccessYes
TypeARTICLE
VenueThe Lancet Planetary Health (JOURNAL)
Journal identifiersISSN: 2542-5196 • E-ISSN: 2542-5196
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.lanplh.2025.101390
PMID41421372
OpenAlexW7115893454
LanguageEN
Citations received1
References cited193

Microplastics and nanoplastics (MNPs) are emerging pollutants widely dispersed in the environment, with humans primarily exposed through ingestion and inhalation. Although their biological effects are being increasingly studied, their potential effect on human health and disease risk remains uncertain. This Review summarises evidence on potential disease risks of human exposure to MNPs, while highlighting key limitations and research gaps. Evidence suggests that MNP exposure might elevate the risk of various diseases, including metabolic, respiratory, cardiovascular, neuroendocrine, hepatic, renal, and skin disorders, as well as infectious diseases, cancer, and ageing-related disorders. Despite extensive evidence of adverse effects in animal models and cell cultures, direct evidence linking MNP exposure to human disease risk remains scarce. A key challenge on research of MNPs lies in the scarcity of robust human exposure data and the narrow scope of existing studies on specific types of MNPs, leaving several environmentally prevalent plastic particles understudied. Addressing these gaps will require investigating the mechanisms of toxicity, relevant biomarkers, and disease pathways associated with MNP exposure. Such efforts will be essential to clarify human health risks and inform future regulatory and mitigation strategies

Disease · Human disease · Human health · Microplastics · Plastic pollution · Risk assessment · Scarcity · Scope (computer science · Microplastics and Plastic Pollution · Nanoparticles: synthesis and applications · Recycling and Waste Management Techniques

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Citations per year1
Citation span2026 - 2026 (1)
Highly citedNo

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