Use of a Cross-over Design in Testing Short-Term Methylphenidate Effects on Avoidance Conditioning
Bibliographic Data
| ID | 13648762 |
|---|---|
| Authors | Eugene F Gauron (University of Iowa, corresponding author), Vinton N Rowley (University of Iowa) |
| Year | 1976 |
| Volume | 39 |
| Issue | 3_suppl |
| Pages | 1183-1187 |
| Publication date | 1976-12-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Psychological Reports (JOURNAL) |
| Journal identifiers | ISSN: 0033-2941 • E-ISSN: 1558-691X |
| Publisher | SAGE Publishing (PUBLISHER • US) |
| DOI | 10.2466/pr0.1976.39.3f.1183 |
| PMID | 1013268 |
| OpenAlex | W2091505738 |
| Language | EN |
| Citations received | 1 |
| References cited | 5 |
90 albino rats, equally divided between the sexes, were divided into groups which received dosages of 4.5 mg/kg, 13.5 mg/kg of methylphenidate and equal volume of distilled water for a total of 8 days. After the initial training period a third of the subjects continued with the same administration while the remaining two-thirds of the animals received the other two dosage combinations. Short-term administration of methylphenidate (Ritalin) facilitated learning as measured by avoidance conditioning. The cross-over design presents advantages over other experimental designs in assessing a variety of possible drug effects. No relationship was obtained between dosage level and response acquisition. However, a linear dose-response relationship was obtained on activity level
Anesthesia · Avoidance response · Conditioning · Crossover study · Dose · Drug administration · Methylphenidate · Placebo · Statistics · Attention Deficit Hyperactivity Disorder · Clinical Psychology · Mathematics · Medicine · Neurobiology and Insect Physiology Research · Neuroscience · Neurotransmitter Receptor Influence on Behavior · Olfactory and Sensory Function Studies · Pharmacology · Psychology
| Citations per year | 0.02 |
|---|---|
| Citation span | 1977 - 1977 (1) |
| Highly cited | No |