Emotional State Can Affect Inflammatory Responses to Pain Among Rheumatoid Arthritis Patients

Preliminary Findings

Bibliographic Data

ID13667672
AuthorsJennifer E Graham-Engeland (0000-0002-9940-2856, Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA, corresponding author), Sunmi Song (0000-0002-8824-9016, Health Risk Prevention Team, Korea Health Promotion Institute, Seoul, Republic of Korea), Ambika Mathur (0000-0001-8010-902X, Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA), David A Wagstaff (Health and Human Development Consulting Group, The Pennsylvania State University, University Park, PA, USA), Laura Cousino Klein (0000-0002-6215-3155, Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA), Courtney A Whetzel (Pennsylvania State University), Courtney Whetzel (Office for Research Protections, The Pennsylvania State University, University Park, PA, USA), William T Ayoub (Allegheny Health Network, Pittsburgh PA)
Year2018
Volume122
Issue6
Pages2026-2049
Publication date2018-09-06
Open AccessYes
TypeARTICLE
VenuePsychological Reports (JOURNAL)
Journal identifiersISSN: 0033-2941 • E-ISSN: 1558-691X
PublisherSAGE Publishing (PUBLISHER • US)
DOI10.1177/0033294118796655
PMID30189801
OpenAlexW2890303751
LanguageEN
Citations received1
References cited61

In a novel pilot study, we investigated how emotional state is related to inflammatory responses to acute pain among women with rheumatoid arthritis. Nine women completed four 5-hour visits that varied only by manipulation of emotion (anger, sadness, happiness, vs. control); in each visit, acute pain was elicited, with blood draws at baseline, 10 minutes, 60 minutes, and 100 minutes post-pain. We examined the effects of within-subjects factors on circulating inflammatory biomarkers interleukin (IL)-6, IL-10, tumor necrosis factor-α, C-reactive protein, and cortisol. There was a main effect of state anger on IL-6, with higher reported anger associated with higher IL-6 across conditions. Further, there were several interactions between state emotion and condition. For example, when individuals reported higher state anger in the sadness condition compared to their own average, they showed higher levels of IL-6 and cortisol. Findings are discussed within a larger literature suggesting that mixed emotional states can contribute to psychological stress and inflammatory responses

Affect (linguistics · Anger · Depression (economics · Happiness · Psychotherapist · Rheumatoid arthritis · Sadness · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Clinical Psychology · Internal Medicine · Medicine · Optimism, Hope, and Well-being · Psychology · Stress Responses and Cortisol

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