Marijuana Intoxication in Rats
Interruption of Recent Memory and Effect on Brain Concentration of Delta 9-Tetrahydrocannabinol
Bibliographic Data
| ID | 13675730 |
|---|---|
| Authors | Eric J Essman (Queens College, of the City, University of New York, corresponding author) |
| Year | 1984 |
| Volume | 55 |
| Issue | 2 |
| Pages | 563-567 |
| Publication date | 1984-10-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Psychological Reports (JOURNAL) |
| Journal identifiers | ISSN: 0033-2941 • E-ISSN: 1558-691X |
| Publisher | SAGE Publishing (PUBLISHER • US) |
| DOI | 10.2466/pr0.1984.55.2.563 |
| PMID | 6096910 |
| OpenAlex | W2069446635 |
| Language | EN |
| References cited | 9 |
Rats exposed to marijuana smoke injected into a chamber immediately after passive avoidance training, showed a significant failure to perform the conditioned avoidance response 24 hr. later. A delivered dose of marijuana resulted in appreciable concentrations of its major behaviorally active metabolite, Δ 9 -tetrahydrocannabinol (Δ 9 -THC) in the absence of gross signs of intoxication, 24 hr. later. The greatest regional brain concentration of Δ 9 -THC occurred in the hippocampus, a region usually associated with memory trace processing and retention. The present study demonstrates that (1) marijuana intoxication can produce a retrograde amnesia in rats and (2) the amnesic effect is likely to depend upon Δ 9 -THC accumulation in the hippocampus and is probably not dependent upon the post-training intoxication state
Amnesia · Anesthesia · Avoidance response · Brain damage · Cannabinoid · Cannabis · Delta-9-tetrahydrocannabinol · Hippocampus · Metabolite · Psychiatry · Retrograde amnesia · Tetrahydrocannabinol · Δ9-tetrahydrocannabinol · Cannabis and Cannabinoid Research · Internal Medicine · Medicine · Memory and Neural Mechanisms · Neuroscience · Neuroscience and Neuropharmacology Research · Pharmacology · Psychology
| Highly cited | No |
|---|