Does cord blood leptin level mediate the association between neonatal body size and postnatal growth? Results from the Eden mother–child cohort study

Bibliographic Data

ID13922207
AuthorsMarion Taine (0000-0001-9277-9645, Centre for Research in Epidemiology and Statistics, INSERM, Université de Paris, INRAe, Paris, France, corresponding author), Olfa Khalfallah (0000-0002-9093-1591, Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, INSERM, Université de Nice-Sophia Antipolis, UMR7275, UMR_S, Valbonne, France), Anne Forhan (Centre for Research in Epidemiology and Statistics, INSERM, Université de Paris, INRAe, Paris, France), Nicolas Glaichenhaus (0000-0002-8997-0470, Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, INSERM, Université de Nice-Sophia Antipolis, UMR7275, UMR_S, Valbonne, France), Marie-Aline Charles (0000-0003-4025-4390, Centre for Research in Epidemiology and Statistics, INSERM, Université de Paris, INRAe, Paris, France), Bénédicte Heude (0000-0002-1565-1629, Centre for Research in Epidemiology and Statistics, INSERM, Université de Paris, INRAe, Paris, France)
Year2020
Volume47
Issue2
Pages159-165
Publication date2020-02-17
Open AccessYes
TypeARTICLE
VenueAnnals of Human Biology (JOURNAL)
Journal identifiersISSN: 0301-4460 • E-ISSN: 1464-5033
PublisherInforma (PUBLISHER • GB)
DOI10.1080/03014460.2020.1748712
PMID32338077
OpenAlexW3018425508
LanguageEN
References cited49

Background : Leptin is potentially involved in the correction of early postnatal growth of infants having deviated from their genetic trajectory in utero. Aim : To analyse the potential mediating role of cord blood leptin level in the association between neonatal anthropometry and early postnatal growth in the mother-child EDEN cohort. Subjects and methods : We included term newborns with information on leptin, birth weight and length, and weight and length SD-score changes over the first 2 months. The Baron and Kenny method was used to quantify the mediation contribution of leptin in the association between neonatal anthropometry and postnatal growth, considering several confounders. Analyses were stratified to consider sexual dimorphism. Results : A 1 SD higher birth weight was associated with a lower 2-months weight variation of 0.27 (0.18; 0.36) SD and a 0.16 (0.06; 0.26) SD, in boys and girls, respectively. Leptin explained 20% and 25% of these associations, respectively. Leptin did not mediate the association between birth length and birth-to-2 months length variation. Conclusion : Our results suggest that cord blood leptin may not be involved in the negative association between birth length and postnatal length growth but may play a modest mediating role in early postnatal catch-up or catch-down in weight

Anthropometry · Biology · Birth weight · Cohort · Cohort study · Confounding · Cord blood · Fetus · Gestational age · In utero · Leptin · Obesity · Obstetrics · Pregnancy · Sexual dimorphism · Birth, Development, and Health · Child Nutrition and Water Access · Medicine · Regulation of Appetite and Obesity · Endocrinology · Internal Medicine · Physiology

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