Infection and childhood leukemia
Review of evidence
Bibliographic Data
| ID | 14458447 |
|---|---|
| Authors | Raquel Da Rocha Paiva Maia, Raquel Maia (0000-0001-6731-6489, Universidade de São Paulo), Victor Wünsch Filho, Victor Wünsch-Filho (0000-0001-5958-1717, Universidade de São Paulo) |
| Year | 2013 |
| Volume | 47 |
| Issue | 6 |
| Pages | 1172-1185 |
| Publication date | 2013-12-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Revista de Saúde Pública (JOURNAL) |
| Journal identifiers | ISSN: 0034-8910 • E-ISSN: 0034-8910 |
| Publisher | FapUNIFESP (SciELO) (PUBLISHER) |
| DOI | 10.1590/s0034-8910.2013047004753 |
| PMID | 24626555 |
| OpenAlex | W2128173570 |
| SCIELO_PID | S0034-89102013000601172 |
| Language | EN |
| Citations received | 1 |
| References cited | 2 |
OBJECTIVE: To analyze studies that evaluated the role of infections as well as indirect measures of exposure to infection in the risk of childhood leukemia, particularly acute lymphoblastic leukemia. METHODS: A search in Medline, Lilacs, and SciELO scientific publication databases initially using the descriptors "childhood leukemia" and "infection" and later searching for the words "childhood leukemia" and "maternal infection or disease" or "breastfeeding" or "daycare attendance" or "vaccination" resulted in 62 publications that met the following inclusion criteria: subject aged ≤ 15 years; specific analysis of cases diagnosed with acute lymphoblastic leukemia or total leukemia; exposure assessment of mothers' or infants' to infections (or proxy of infection), and risk of leukemia. RESULTS: Overall, 23 studies that assessed infections in children support the hypothesis that occurrence of infection during early childhood reduces the risk of leukemia, but there are disagreements within and between studies. The evaluation of exposure to infection by indirect measures showed evidence of reduced risk of leukemia associated mainly with daycare attendance. More than 50.0% of the 16 studies that assessed maternal exposure to infection observed increased risk of leukemia associated with episodes of influenza, pneumonia, chickenpox, herpes zoster, lower genital tract infection, skin disease, sexually transmitted diseases, Epstein-Barr virus, and Helicobacter pylori . CONCLUSIONS: Although no specific infectious agent has been identified, scientific evidence suggests that exposure to infections has some effect on childhood leukemia etiology
Childhood leukemia · Leukemia · Lymphoblastic Leukemia · Acute Lymphoblastic Leukemia research · Childhood Cancer Survivors' Quality of Life · Immunology · Medicine · Neutropenia and Cancer Infections
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,2 |
| Citation span | 2021 - 2021 (1) |
| Citation velocity | historical |
| Highly cited | No |