On the rumors about the silent spring
Review of the scientific evidence linking occupational and environmental pesticide exposure to endocrine disruption health effects
Bibliographic Data
| ID | 14618528 |
|---|---|
| Authors | Pierluigi Cocco (0000-0001-8256-7614, University of Cagliari, corresponding author) |
| Year | 2002 |
| Volume | 18 |
| Issue | 2 |
| Pages | 379-402 |
| Publication date | 2002-04-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Cadernos de Saude Publica (JOURNAL) |
| Journal identifiers | ISSN: 0102-311X • E-ISSN: 1678-4464 |
| Publisher | FapUNIFESP (SciELO) (PUBLISHER) |
| DOI | 10.1590/s0102-311x2002000200003 |
| PMID | 11923880 |
| OpenAlex | W2135245454 |
| SciELO | S0102-311X2002000200003 |
| Language | EN |
| Citations received | 7 |
| References cited | 130 |
Occupational exposure to some pesticides, and particularly DBCP and chlordecone, may adversely affect male fertility. However, apart from the therapeutic use of diethylstilbestrol, the threat to human reproduction posed by "endocrine disrupting" environmental contaminants has not been supported by epidemiological evidence thus far. As it concerns other endocrine effects described in experimental animals, only thyroid inhibition following occupational exposure to amitrole and mancozeb has been confirmed in humans. Cancer of the breast, endometrium, ovary, prostate, testis, and thyroid are hormone-dependent, which fostered research on the potential risk associated with occupational and environmental exposure to the so-called endocrine-disrupting pesticides. The most recent studies have ruled out the hypothesis of DDT derivatives as responsible for excess risks of cancer of the reproductive organs. Still, we cannot exclude a role for high level exposure to o,p'-DDE, particularly in post-menopausal ER+ breast cancer. On the other hand, other organochlorine pesticides and triazine herbicides require further investigation for a possible etiologic role in some hormone-dependent cancers
Biology · Diethylstilbestrol · Endocrine disruptor · Endocrine system · Environmental health · Fungicide · Gynecology · Hormone · Mancozeb · Pesticide · Thyroid · Thyroid cancer · Carcinogens and Genotoxicity Assessment · Ecology · Effects and risks of endocrine disrupting chemicals · Endocrinology · Medicine · Physiology · Toxic Organic Pollutants Impact · Toxicology
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Vigilância aos agrotóxicos
Existen relaciones entre los factores ambientales rurales y la salud reproductiva en la Pampa Húmeda Argentina
DDT reintroduction for malaria control
Saúde e ambiente em sua relação com o consumo de agrotóxicos em um pólo agrícola do Estado do Rio de Janeiro, Brasil
A produção científica sobre o ambiente na saúde coletiva
| Citations per year | 0.33 |
|---|---|
| Citation span | 2005 - 2014 (10) |
| Highly cited | No |