A systematic review of mercury ototoxicity

Bibliographic Data

ID14618670
AuthorsAna Cristina Hiromi Hoshino (0000-0003-0501-3954, Universidade Federal do Rio de Janeiro), Heloisa Pacheco Ferreira (Universidade Federal do Rio de Janeiro), Olaf Malm (0000-0002-4116-7160, Universidade Federal do Rio de Janeiro), Renata Mamede Carvallo (Universidade de São Paulo), Volney Magalhães Câmara (Universidade Federal do Rio de Janeiro)
Year2012
Volume28
Issue7
Pages1239-1248
Publication date2012-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueCadernos de Saude Publica (JOURNAL)
Journal identifiersISSN: 0102-311X • E-ISSN: 1678-4464
PublisherFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/s0102-311x2012000700003
SCIELO_PIDS0102-311X2012000700003
LanguageEN
Citations received1
References cited30

Mercury is neurotoxic, and numerous studies have confirmed its ototoxic effect. However, the diagnosis and follow-up of mercury exposure require understanding the pathophysiology of the chemical substance. Based on a systematic literature review, this study aimed to demonstrate whether mercury is ototoxic and to analyze its mechanism of action on the peripheral and central auditory system, in order to contribute to the diagnosis and follow-up of exposure. This was a systematic review of studies published on the effects of mercury exposure on the auditory system. The full text of the studies and their methodological quality were analyzed. The review identified 108 studies published on the theme, of which 28 met the inclusion criteria. All the articles in the analysis showed that mercury exposure is ototoxic and produces peripheral and/or central damage. Acute and long-term exposure produces irreversible damage to the central auditory system. Biomarkers were unable to predict the relationship between degree of mercury poisoning and degree of lesion in the auditory system

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