Geographical and social class differentials in stroke mortality--the influence of early-life factors
Comments on papers by Maheswaran and colleagues
Bibliographic Data
| ID | 14622994 |
|---|---|
| Authors | Gregory D Smith (0000-0002-1407-8314, University of Bristol), Yoav Ben-Shlomo (0000-0001-6648-3007, University of Bristol) |
| Year | 1997 |
| Volume | 51 |
| Issue | 2 |
| Pages | 134-137 |
| Publication date | 1997-04-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech.51.2.134 |
| PMID | 9196641 |
| OpenAlex | W2144127958 |
| Language | EN |
| Citations received | 5 |
| References cited | 32 |
The processes of cell proliferation, differentiation, migration, and self-organization during early embryonic development are governed by dynamic, spatially and temporally varying morphogen signals. Analogous tissue patterns emerge spontaneously in embryonic stem cell (ESC) models for gastrulation, but mechanistic insight into this self-organization is limited by a lack of molecular methods to precisely control morphogen signal dynamics. Here we combine optogenetic stimulation and single-cell imaging approaches to study self-organization of human pluripotent stem cells. Precise control of morphogen signal dynamics, achieved through activation of canonical Wnt/β-catenin signaling over a broad high dynamic range (>500-fold) using an optoWnt optogenetic system, drove broad transcriptional changes and mesendoderm differentiation of human ESCs at high efficiency (>95% cells). Furthermore, activating Wnt signaling in subpopulations of ESCs in 2D and 3D cultures induced cell self-organization and morphogenesis reminiscent of human gastrulation, including changes in cell migration and epithelial to mesenchymal transition. Our findings thus reveal an instructive role for Wnt in directing cell patterning in this ESC model for gastrulation
Biology · Embryo · Embryogenesis · Embryonic stem cell · Gastrulation · Morphogen · Morphogenesis · Optogenetics · Signal transduction · Wnt signaling pathway · Zebrafish · Birth, Development, and Health · Cell Biology · Genetics · Health, Environment, Cognitive Aging · Neuroscience · Pregnancy and preeclampsia studies
Differential Mortality in the United States
Understanding the Effects of Age, Period, and Cohort on Incidence and Mortality Rates
Fetal origins of coronary heart disease
Deprivation in infancy or in adult life
Epidemiology of Cardiovascular Mortality—Geographic and Ethnic
Height and mortality in the counties of England and Wales
On Maternal and Infant Mortality 1900-1960
Stroke
Social-class inequality in infant mortality in England and Wales from 1921 to 1980
Adult height and mortality in London
Childhood socioeconomic status and risk of cardiovascular disease in middle aged US women
Socioeconomic deprivation, ethnicity, and stroke mortality in Greater London and south east England
Childhood leg length and adult mortality
Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease
Trends in stroke mortality in Greater London and south east England--evidence for a cohort effect
Infant mortality by Father’s occupation from the 1911 Census of England and Wales
The Geography of Death in England and Wales 1
| Citations per year | 0.18 |
|---|---|
| Citation span | 1998 - 2005 (8) |
| Highly cited | No |