Tuberculosis and leprosy associated with historical human population movements in Europe and beyond – an overview based on mycobacterial ancient DNA
Bibliographic Data
| ID | 14679691 |
|---|---|
| Authors | Helen D Donoghue (0000-0003-3918-5252, ,, corresponding author) |
| Year | 2019 |
| Volume | 46 |
| Issue | 2 |
| Pages | 120-128 |
| Publication date | 2019-02-17 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Annals of Human Biology (JOURNAL) |
| Journal identifiers | ISSN: 0301-4460 • E-ISSN: 1464-5033 |
| Publisher | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/03014460.2019.1624822 |
| PMID | 31137975 |
| OpenAlex | W2947371251 |
| Language | EN |
| Citations received | 4 |
| References cited | 73 |
Context: Tuberculosis and leprosy are readily recognised in human remains due to their typical palaeopathology. Both Mycobacterium tuberculosis (MTB) and Mycobacterium leprae (ML) are obligate pathogens and have been detected in ancient human populations.Objective: To demonstrate historical tuberculosis and leprosy cases in Europe and beyond using molecular methods, as human populations are associated with different mycobacterial genotypes.Methods: MTB and ML ancient DNA (aDNA) has been detected by DNA amplification using PCR, or by whole genome sequencing. Mycobacterial cell wall lipids also provide specific markers for identification.Results: In 18th century Hungary, the European indigenous MTB genotype 4 strains have been found. However, many individuals were co-infected with up to three MTB sub-genotypes. In 8th–14th century Europe significant differences in ML genotypes were found between northwest Europe compared with central, southern, or eastern Europe. In addition, several co-infections of MTB and ML were detected in historical samples.Conclusion: Both MTB and ML strain types differ between geographically separate populations. This is associated with ancient human migration after an evolutionary bottleneck and clonal expansion. The absence of indigenous leprosy in Europe today may be due to the greater mortality of tuberculosis in individuals who are co-infected with both organisms
Ancient DNA · Biology · Environmental health · Gene · Genotype · Leprosy · Mycobacterium leprae · Mycobacterium tuberculosis · Mycobacterium tuberculosis complex · Paleopathology · Pathology · Population · Tuberculosis · Leprosy Research and Treatment · Medicine · Mycobacterium research and diagnosis · Tuberculosis Research and Epidemiology · Genetics · Immunology
Diseases in antiquity
Identification of Mycobacterium tuberculosis DNA in a pre-Columbian Peruvian mummy.
Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
Genetic Analyses from Ancient DNA
The use of the polymerase chain reaction (PCR) to detect Mycobacterium tuberculosis in ancient skeletons
Complex DNA in Ancient Human Bones
A Mediaeval Case of Lepromatous Leprosy from 13–14th Century Orkney, Scotland
Mycobacterium leprae genotype amplified from an archaeological case of lepromatous leprosy in Central Asia
Variable nucleotide tandem repeat (VNTR) typing of two palaeopathological cases of lepromatous leprosy from Mediaeval England
Widespread occurrence of Mycobacterium tuberculosis DNA from 18th–19th century Hungarians
Pre‐Columbian tuberculosis in Northern Chile
Brief communication
Probable early presence of leprosy in Europe in a Celtic skeleton of the 4th-3rd century BC (Casalecchio di Reno, Bologna, Italy)
Prehistory of human tuberculosis
Molecular evidence for different stages of tuberculosis in ancient bone samples from Hungary
The genome sequence of a SNP type 3K strain of Mycobacterium leprae isolated from a seventh-century Hungarian case of lepromatous leprosy
Paleopathological and Molecular Study on Two Cases of Ancient Childhood Leprosy from the Roman and Byzantine Empires
Molecular history of tuberculosis from ancient mummies and skeletons
DNA of Mycobacterium leprae detected by PCR in ancient bone
A Late Neolithic Case of Pott's Disease from Hungary
Two Early Cases of Leprosy in Great Britain
| Citations per year | 0.57 |
|---|---|
| Citation span | 2019 - 2024 (6) |
| Highly cited | No |