Therapeutic potential of traditional Chinese medicine for interstitial lung disease
Bibliographic Data
| ID | 14726744 |
|---|---|
| Authors | Yan-Ming Zhou (Tianjin University of Traditional Chinese Medicine), Xin-Ran Dong, Xinran Dong (0000-0001-9868-8795, Second Hospital of Tianjin Medical University), Dong Xu (0000-0001-7022-4518, Tianjin University of Traditional Chinese Medicine, corresponding author), Jie Tang (0009-0004-2754-9463, Tianjin University of Traditional Chinese Medicine), Yuan-Lu Cui (0000-0003-4392-3713, Tianjin University of Traditional Chinese Medicine, corresponding author) |
| Year | 2024 |
| Volume | 318 |
| Issue | Pt A |
| Pages | 116952 |
| Publication date | 2024-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2023.116952 |
| PMID | 37487964 |
| OpenAlex | W4385163731 |
| Language | EN |
| Citations received | 1 |
| References cited | 116 |
ETHNOPHARMACOLOGICAL RELEVANCE: Interstitial lung disease (ILD) is a chronic lung dysfunction disease with a poor prognosis and poor recovery. The clinically used therapeutic drugs, such as glucocorticoids and immunosuppressants, have no significant therapeutic effect and are accompanied with severe side effects. In recent years, considerable progress has been made in exploring and applying natural herb components for treating ILD. Traditional Chinese Medicine (TCM) possesses innate, non-toxic characteristics and offers advantages in preventing and treating pulmonary ailments. However, a comprehensive study of TCM on ILD therapy has not yet been reviewed. AIM OF THE REVIEW: This review aimed to provide a comprehensive summary of the monomer components, total extracts, and prescriptions of TCM for ILD therapy, elucidating their molecular mechanisms to serve as a reference in treating ILD. MATERIALS AND METHODS: The literature information was searched in the PubMed, Web of Science databases. The search keywords included 'interstitial lung disease', 'lung fibrosis' or 'pulmonary fibrosis', and 'traditional Chinese medicine', 'traditional herbal medicine', or 'herb medicine'. RESULTS: The active components of single herbs, such as alkaloids, flavonoids, terpenoids, phenols, and quinones, have potential therapeutic effects on ILD. The active extracts and prescriptions were also summarized and analyzed. The herbs, Glycyrrhiza uralensis Fisch. (Gancao), Astragalus membranaceus Fisch. Bunge. (Huangqi) and Angelicasinensis (Oliv.) Diels (Danggui), play significant roles in the treatment of ILD. The mechanisms involve the inhibition of inflammatory factor release, anti-oxidative injury, and interference with collagen production, etc. CONCLUSION: This review examines the therapeutic potential of TCM for ILD and elucidates its molecular mechanisms, demonstrating that mitigating inflammation and oxidative stress, modulating the immune system, and promoting tissue repair are efficacious strategies for ILD therapy. The depth research will yield both theoretical and practical implications
Alternative medicine · Angelica sinensis · Astragalus · Glycyrrhiza uralensis · Interstitial lung disease · Lung · Pathology · Traditional Chinese medicine · Traditional medicine · Tripterygium wilfordii · Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis · Medicine · Quinazolinone synthesis and applications · Traditional Chinese Medicine Analysis · Internal Medicine · Pharmacology
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| Unique citing works | 1 |
|---|---|
| Citations per year | 1 |
| Citation span | 2025 - 2025 (1) |
| Citation velocity | recent |
| Highly cited | No |