Multi-omics analysis of Gwakhyangjeonggi-san for gastrointestinal complications in atopic dermatitis
A randomized, double-blinded, placebo-controlled, parallel-group clinical trial
Bibliographic Data
| ID | 14727175 |
|---|---|
| Authors | Mi Mi Ko (0000-0002-5758-4655, Korea Institute of Oriental Medicine), Sarah Shin (0000-0001-7046-9021, Korea Institute of Oriental Medicine), Min Hee Kim (0000-0003-0829-1968, Kyung Hee University Hospital at Gangdong, corresponding author), Minseo Kang (0009-0004-8746-7240), Min-Seo Kang (0009-0006-1069-7827, Kyung Hee University Hospital at Gangdong), Min-gyung Baek (0000-0001-6319-5405, Korea University), Hana Yi (0000-0002-4910-122X, Korea University), Mi Ju Son (0000-0003-1701-9122, Korea Institute of Oriental Medicine), Jeeyoun Jung (0000-0002-9213-4748, Korea Institute of Oriental Medicine, corresponding author) |
| Year | 2024 |
| Volume | 319 |
| Issue | Pt 2 |
| Pages | 117256 |
| Publication date | 2024-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2023.117256 |
| PMID | 37778520 |
| OpenAlex | W4387167352 |
| Language | EN |
| References cited | 35 |
These results showed that the GJS had no significant effect on AD compared to the placebo but exerted a beneficial effect on improving the quality of life and gastrointestinal symptoms in patients with AD, and it acted by modulating gut microbiome diversity and gut microbiome-derived uremic toxins. Our findings support the use of GJS for AD comorbidities and also provide evidence that multi-omics approaches can be useful for understanding herbal decoctions in TCM and TKM comprehensively
Adverse effect · Alternative medicine · Atopic dermatitis · Clinical trial · Dermatology Life Quality Index · Pathology · Placebo · Quality of life (healthcare · Randomized controlled trial · Asthma and respiratory diseases · Dermatology and Skin Diseases · Exercise and Physiological Responses · Medicine · Dermatology · Gastroenterology · Internal Medicine
| Highly cited | No |
|---|