The molecular mechanisms of Caulophyllum robustum Maxim extract inhibition by regulating FAK/PI3K signaling pathway in gastric cancer HGC-27 cells
Bibliographic Data
| ID | 14727508 |
|---|---|
| Authors | Minghua Cui (0009-0002-8148-1215, Yanbian University), Guangyuan Yao (0000-0003-0897-2237, State Ethnic Affairs Commission), Yingying Zhang (0009-0003-0758-2832, Yanbian University), Meixin Wen (Yanbian University), Shengjun Zhang (0000-0002-4001-7232, Yanbian University), Jingchun Jin (0000-0002-3985-2513, Yanbian University), Zhenhua Lin (0000-0003-0279-3166, Yanbian University), Xiangshan Ren (0000-0003-0914-1814, Yanbian University), Renbo An, Ren‐Bo An (0000-0002-2564-0747, Yanbian University, corresponding author), Yingshi Piao (0000-0002-7466-1595, Yanbian University, corresponding author) |
| Year | 2025 |
| Volume | 337 |
| Issue | Pt 2 |
| Pages | 118867 |
| Publication date | 2025-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2024.118867 |
| PMID | 39369918 |
| OpenAlex | W4403117416 |
| Language | EN |
| References cited | 24 |
The anti-tumor components of CRME, Cauloside A and Cauloside C, inhibited tumor progression in HGC-27 cells. This inhibition is achieved by decreasing the phosphorylation levels of FAK, thereby modulating PI3K/AKT signaling pathway
Cancer · Maxim · PI3K/AKT/mTOR pathway · Signal transduction · Traditional medicine · Chemistry · Medicine · Natural product bioactivities and synthesis · Philosophy · Phytochemical compounds biological activities · Phytochemistry and Bioactive Compounds · Biochemistry · Cancer Research · Internal Medicine · Pharmacology
| Highly cited | No |
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