Panax notoginseng saponins inhibits oxidative stress- induced human nucleus pulposus cell apoptosis and delays disc degeneration in vivo and in vitro

Bibliographic Data

ID14727700
AuthorsDanqing Guo (0000-0002-9538-2237, Guangzhou University of Chinese Medicine, corresponding author), Miao Yu (0000-0002-7625-6315, Guangzhou University of Chinese Medicine), Huizhi Guo (0000-0003-3952-0030, Guangzhou University of Chinese Medicine), Min Zeng (0009-0006-3980-8666, Guangzhou University of Chinese Medicine), Yang Shao (0000-0002-5854-3257, Guangzhou University of Chinese Medicine), Wei Deng (0000-0002-1243-3044, Guangzhou University of Chinese Medicine), Qiuli Qin (Guangzhou University of Chinese Medicine), Yongxian Li (0000-0002-4897-1194, Guangzhou University of Chinese Medicine), Shuncong Zhang (0000-0002-6212-9913), Shun-cong Zhang (Guangzhou University of Chinese Medicine, corresponding author)
Year2024
Volume319
IssuePt 1
Pages117166
Publication date2024-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.117166
PMID37716491
OpenAlexW4386785408
LanguageEN
References cited38

Our study showed that PNS could protect HNP cells against apoptosis via autophagy inhibition and ameliorate disc degeneration in vivo, indicating its potential to be a therapeutic agent for IDD

Apoptosis · Autophagy · Biology · In vitro · In vivo · Intervertebral disc · Oxidative stress · Panax notoginseng · Pathology · TUNEL assay · Western blot · Chemistry · Medicine · Musculoskeletal pain and rehabilitation · Plant Toxicity and Pharmacological Properties · Spine and Intervertebral Disc Pathology · Anatomy · Biochemistry · Cell Biology · Pharmacology